Expression of CGNL1 in cancer - Summary

GENERAL INFORMATION
Gene name	CGNL1
Gene description	Cingulin-like 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HUVEC TERT2, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Luminal membranous expression, mainly in kidney tubules, salivary gland, prostate, exocrine pancreas and endothelial cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA056911 , CAB013500
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA056911	CAB013500

GENE INFORMATION
Gene name	CGNL1 (HGNC Symbol)
Synonyms	FLJ14957, JACOP, KIAA1749, paracingulin
Description	Cingulin-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Chromosome	15
Cytoband	q21.3
Chromosome location (bp)	57375967 - 57550727
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128849 (version 83.38)
Entrez gene	84952
UniProt	Q0VF96 (UniProt - Evidence at protein level)
neXtProt	NX_Q0VF96
Antibodypedia	CGNL1 antibodies

PROTEIN BROWSER

CGNL1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CGNL1-001 ENSP00000281282 ENST00000281282	Q0VF96 [Direct mapping] Cingulin-like protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0005923 [bicellular tight junction] GO:0008152 [metabolic process] GO:0015629 [actin cytoskeleton] GO:0016459 [myosin complex] GO:0043296 [apical junction complex] Show all	1302 aa 149.1 kDa	No	0