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TMOD2

GENERAL INFORMATION

Gene name

 TMOD2

Gene description

 Tropomodulin 2 (neuronal)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (SCLC-21H)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA041365
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041365

GENE INFORMATION

Gene name

 TMOD2 (HGNC Symbol)

Synonyms

 NTMOD

Description

 Tropomodulin 2 (neuronal) (HGNC Symbol)

Entrez gene summary

 This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 51751561 - 51816368

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128872 (version 83.38)

Entrez gene

 29767

UniProt

 Q9NZR1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZR1

Antibodypedia

 TMOD2 antibodies

PROTEIN BROWSER
TMOD2-001
TMOD2-002
TMOD2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TMOD2-001
ENSP00000249700
ENST00000249700
Q9NZR1 [Direct mapping]
Tropomodulin-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005523 [tropomyosin binding]
GO:0005856 [cytoskeleton]
GO:0005865 [striated muscle thin filament]
GO:0006936 [muscle contraction]
GO:0007015 [actin filament organization]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007399 [nervous system development]
GO:0007611 [learning or memory]
GO:0030016 [myofibril]
GO:0030239 [myofibril assembly]
GO:0030426 [growth cone]
GO:0043005 [neuron projection]
GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway]
GO:0048821 [erythrocyte development]
GO:0051694 [pointed-end actin filament capping]
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 351 aa
39.6 kDa 		No 0
TMOD2-002
ENSP00000437743
ENST00000539962
G5EA42 [Direct mapping]
Tropomodulin 2 (Neuronal), isoform CRA_a; Tropomodulin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005523 [tropomyosin binding]
GO:0005856 [cytoskeleton]
GO:0005865 [striated muscle thin filament]
GO:0006936 [muscle contraction]
GO:0007015 [actin filament organization]
GO:0030016 [myofibril]
GO:0030239 [myofibril assembly]
GO:0048821 [erythrocyte development]
GO:0051694 [pointed-end actin filament capping]
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 307 aa
34.5 kDa 		No 0
TMOD2-004
ENSP00000404590
ENST00000435126
Q9NZR1 [Direct mapping]
Tropomodulin-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005523 [tropomyosin binding]
GO:0005856 [cytoskeleton]
GO:0005865 [striated muscle thin filament]
GO:0006936 [muscle contraction]
GO:0007015 [actin filament organization]
GO:0007399 [nervous system development]
GO:0030016 [myofibril]
GO:0030239 [myofibril assembly]
GO:0048821 [erythrocyte development]
GO:0051694 [pointed-end actin filament capping]
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 315 aa
35.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.