Expression of TTBK2 in cancer - Summary

GENERAL INFORMATION
Gene name	TTBK2
Gene description	Tau tubulin kinase 2
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues including cilia in fallopian tube and sperm in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 2 antibodies. HPA018113 , HPA049866
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA018113	HPA049866

GENE INFORMATION
Gene name	TTBK2 (HGNC Symbol)
Synonyms	KIAA0847, SCA11
Description	Tau tubulin kinase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
Chromosome	15
Cytoband	q15.2
Chromosome location (bp)	42738734 - 42920809
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128881 (version 83.38)
Entrez gene	146057
UniProt	Q6IQ55 (UniProt - Evidence at protein level)
neXtProt	NX_Q6IQ55
Antibodypedia	TTBK2 antibodies

PROTEIN BROWSER

TTBK2-001	TTBK2-002	TTBK2-003	TTBK2-006	TTBK2-007	TTBK2-008	TTBK2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTBK2-001 ENSP00000267890 ENST00000267890	Q6IQ55 [Direct mapping] Tau-tubulin kinase 2 Show all	Enzymes ENZYME proteins Transferases Kinases CK1 Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006996 [organelle organization] GO:0007224 [smoothened signaling pathway] GO:0008360 [regulation of cell shape] GO:0018105 [peptidyl-serine phosphorylation] GO:0035869 [ciliary transition zone] GO:0036064 [ciliary basal body] GO:0042384 [cilium assembly] Show all	1244 aa 137.4 kDa	No	0
TTBK2-002 ENSP00000455734 ENST00000567840	Q6IQ55 [Direct mapping] Tau-tubulin kinase 2 Show all	Enzymes ENZYME proteins Transferases Kinases CK1 Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006996 [organelle organization] GO:0007224 [smoothened signaling pathway] GO:0008360 [regulation of cell shape] GO:0018105 [peptidyl-serine phosphorylation] GO:0035869 [ciliary transition zone] GO:0036064 [ciliary basal body] GO:0042384 [cilium assembly] Show all	478 aa 54 kDa	No	0
TTBK2-003 ENSP00000457489 ENST00000567274	A0A0B4J292 [Direct mapping] Tau-tubulin kinase 2 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008360 [regulation of cell shape] Show all	443 aa 50.1 kDa	No	0
TTBK2-006 ENSP00000457385 ENST00000562880	H3BTY5 [Direct mapping] Tau-tubulin kinase 2 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008360 [regulation of cell shape] Show all	143 aa 16.1 kDa	No	0
TTBK2-007 ENSP00000455574 ENST00000564431	H3BQ25 [Direct mapping] Tau-tubulin kinase 2 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0008360 [regulation of cell shape] Show all	117 aa 12.8 kDa	No	0
TTBK2-008 ENSP00000454605 ENST00000566931	H3BMY7 [Direct mapping] Tau-tubulin kinase 2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0008360 [regulation of cell shape] Show all	84 aa 9.2 kDa	No	0
TTBK2-201 ENSP00000479984 ENST00000622375	Q8IWY7 [Direct mapping] Tau-tubulin kinase; Tau-tubulin kinase 2 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005198 [structural molecule activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005882 [intermediate filament] GO:0006468 [protein phosphorylation] GO:0008360 [regulation of cell shape] GO:0045095 [keratin filament] Show all	1649 aa 182.5 kDa	No	0