Expression of IVD in cancer - Summary - The Human Protein Atlas

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IVD

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IVD
Gene description	Isovaleryl-CoA dehydrogenase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA041391 , HPA044250
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041391	HPA044250

GENE INFORMATION
Gene name	IVD (HGNC Symbol)
Synonyms	ACAD2
Description	Isovaleryl-CoA dehydrogenase (HGNC Symbol)
Entrez gene summary	Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40405795 - 40435947
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128928 (version 83.38)
Entrez gene	3712
UniProt	P26440 (UniProt - Evidence at protein level)
neXtProt	NX_P26440
Antibodypedia	IVD antibodies

PROTEIN BROWSER

IVD-001	IVD-002	IVD-004	IVD-006	IVD-008	IVD-009	IVD-012	IVD-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IVD-001 ENSP00000418397 ENST00000487418	A0A0A0MT83 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0005759 [mitochondrial matrix] GO:0008152 [metabolic process] GO:0008470 [isovaleryl-CoA dehydrogenase activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0031966 [mitochondrial membrane] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	426 aa 46.7 kDa	No	0
IVD-002 ENSP00000417990 ENST00000479013	P26440 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006552 [leucine catabolic process] GO:0008152 [metabolic process] GO:0008470 [isovaleryl-CoA dehydrogenase activity] GO:0009055 [electron carrier activity] GO:0009083 [branched-chain amino acid catabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process] Show all	396 aa 43.1 kDa	No	0
IVD-004 ENSP00000479359 ENST00000610693	A0A087WVD3 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	214 aa 23.3 kDa	No	0
IVD-006 ENSP00000417256 ENST00000473112	H7C4G6 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	307 aa 32.8 kDa	No	0
IVD-008 ENSP00000454145 ENST00000466756	H0YNT5 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.2 kDa	No	0
IVD-009 ENSP00000453146 ENST00000491554	H0YLC3 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	243 aa 26.4 kDa	No	0
IVD-012 ENSP00000453929 ENST00000559575	H0YNA4 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		41 aa 4.1 kDa	No	0
IVD-013 ENSP00000453821 ENST00000558610	H0YN10 [Direct mapping] Isovaleryl-CoA dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003995 [acyl-CoA dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	212 aa 23.4 kDa	No	0

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