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DUT

GENERAL INFORMATION

Gene name

 DUT

Gene description

 Deoxyuridine triphosphatase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, the antibodies may recognize alternative splice forms and therefore show different subcellular locations.

Reliability score

 Supported based on 2 antibodies.
HPA054422 , HPA060360
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054422
HPA060360

GENE INFORMATION

Gene name

 DUT (HGNC Symbol)

Synonyms

 dUTPase

Description

 Deoxyuridine triphosphatase (HGNC Symbol)

Entrez gene summary

 This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q21.1

Chromosome location (bp)

 48331011 - 48343373

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128951 (version 83.38)

Entrez gene

 1854

UniProt

 P33316 (UniProt - Evidence at protein level)

neXtProt

 NX_P33316

Antibodypedia

 DUT antibodies

PROTEIN BROWSER
DUT-001
DUT-003
DUT-004
DUT-006
DUT-007
DUT-008
DUT-009
DUT-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUT-001
ENSP00000370376
ENST00000331200
P33316 [Direct mapping]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0004170 [dUTP diphosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006226 [dUMP biosynthetic process]
GO:0006260 [DNA replication]
GO:0016787 [hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046080 [dUTP metabolic process]
GO:0046081 [dUTP catabolic process]
GO:0046134 [pyrimidine nucleoside biosynthetic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 252 aa
26.6 kDa 		No 0
DUT-003
ENSP00000405160
ENST00000455976
P33316 [Direct mapping]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004170 [dUTP diphosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006226 [dUMP biosynthetic process]
GO:0006260 [DNA replication]
GO:0016787 [hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046080 [dUTP metabolic process]
GO:0046081 [dUTP catabolic process]
GO:0046134 [pyrimidine nucleoside biosynthetic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 164 aa
17.7 kDa 		No 0
DUT-004
ENSP00000454041
ENST00000559540
H0YNJ9 [Direct mapping]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004170 [dUTP diphosphatase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006226 [dUMP biosynthetic process]
GO:0016787 [hydrolase activity]
GO:0046080 [dUTP metabolic process]
GO:0046081 [dUTP catabolic process]
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 143 aa
15.5 kDa 		No 0
DUT-006
ENSP00000453717
ENST00000558813
A0A0C4DGL3 [Direct mapping]
DUTP pyrophosphatase, isoform CRA_c; Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004170 [dUTP diphosphatase activity]
GO:0005737 [cytoplasm]
GO:0006226 [dUMP biosynthetic process]
GO:0016787 [hydrolase activity]
GO:0046080 [dUTP metabolic process]
GO:0046081 [dUTP catabolic process]
Show all
 141 aa
15.4 kDa 		No 0
DUT-007
ENSP00000453667
ENST00000559935
H0YMM5 [Direct mapping]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004170 [dUTP diphosphatase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006226 [dUMP biosynthetic process]
GO:0016787 [hydrolase activity]
GO:0046080 [dUTP metabolic process]
GO:0046081 [dUTP catabolic process]
Show all
 133 aa
14.3 kDa 		No 0
DUT-008
ENSP00000454183
ENST00000559416
H0YNW5 [Direct mapping]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004170 [dUTP diphosphatase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006226 [dUMP biosynthetic process]
GO:0016787 [hydrolase activity]
GO:0046080 [dUTP metabolic process]
GO:0046081 [dUTP catabolic process]
Show all
 167 aa
17.8 kDa 		No 0
DUT-009
ENSP00000452749
ENST00000558472
H0YKC5 [Direct mapping]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004170 [dUTP diphosphatase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006226 [dUMP biosynthetic process]
GO:0016787 [hydrolase activity]
GO:0046080 [dUTP metabolic process]
GO:0046081 [dUTP catabolic process]
Show all
 221 aa
23.7 kDa 		No 0
DUT-010
ENSP00000453683
ENST00000558367
H0YMP1 [Direct mapping]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004170 [dUTP diphosphatase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006226 [dUMP biosynthetic process]
GO:0016787 [hydrolase activity]
GO:0046080 [dUTP metabolic process]
GO:0046081 [dUTP catabolic process]
Show all
 107 aa
11.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.