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ARPP19

GENERAL INFORMATION

Gene name

 ARPP19

Gene description

 CAMP-regulated phosphoprotein, 19kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA056851
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA056851

GENE INFORMATION

Gene name

 ARPP19 (HGNC Symbol)

Synonyms

 ARPP-16, ARPP-19, ARPP16, ENSAL

Description

 CAMP-regulated phosphoprotein, 19kDa (HGNC Symbol)

Entrez gene summary

 The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 52547045 - 52569883

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128989 (version 83.38)

Entrez gene

 10776

UniProt

 P56211 (UniProt - Evidence at protein level)

neXtProt

 NX_P56211

Antibodypedia

 ARPP19 antibodies

PROTEIN BROWSER
«
ARPP19-001
ARPP19-002
ARPP19-003
ARPP19-004
ARPP19-005
ARPP19-006
ARPP19-007
ARPP19-008
ARPP19-009
ARPP19-010
ARPP19-011
ARPP19-012
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARPP19-001
ENSP00000455625
ENST00000566423
P56211 [Direct mapping]
cAMP-regulated phosphoprotein 19
A0A024R5U3 [Target identity:100%; Query identity:100%]
Cyclic AMP phosphoprotein, 19 kD, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0015459 [potassium channel regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046326 [positive regulation of glucose import]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 112 aa
12.3 kDa 		No 0
ARPP19-002
ENSP00000249822
ENST00000249822
P56211 [Direct mapping]
cAMP-regulated phosphoprotein 19
A0A024R5U3 [Target identity:100%; Query identity:100%]
Cyclic AMP phosphoprotein, 19 kD, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0015459 [potassium channel regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046326 [positive regulation of glucose import]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 112 aa
12.3 kDa 		No 0
ARPP19-003
ENSP00000454234
ENST00000561650
P56211 [Direct mapping]
cAMP-regulated phosphoprotein 19
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0015459 [potassium channel regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046326 [positive regulation of glucose import]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 96 aa
10.6 kDa 		No 0
ARPP19-004
ENSP00000454341
ENST00000561971
H3BMD8 [Direct mapping]
cAMP-regulated phosphoprotein 19
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007212 [dopamine receptor signaling pathway]
GO:0046579 [positive regulation of Ras protein signal transduction]
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 131 aa
14.5 kDa 		No 0
ARPP19-005
ENSP00000455986
ENST00000563277
P56211 [Direct mapping]
cAMP-regulated phosphoprotein 19
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0015459 [potassium channel regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046326 [positive regulation of glucose import]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 96 aa
10.6 kDa 		No 0
ARPP19-006
ENSP00000457123
ENST00000567830
H3BTD3 [Direct mapping]
cAMP-regulated phosphoprotein 19
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 72 aa
8.1 kDa 		No 0
ARPP19-007
ENSP00000455151
ENST00000567669
P56211 [Direct mapping]
cAMP-regulated phosphoprotein 19
A0A024R5U3 [Target identity:100%; Query identity:100%]
Cyclic AMP phosphoprotein, 19 kD, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0015459 [potassium channel regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046326 [positive regulation of glucose import]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 112 aa
12.3 kDa 		No 0
ARPP19-008
ENSP00000454297
ENST00000569281
P56211 [Direct mapping]
cAMP-regulated phosphoprotein 19
A0A024R5U3 [Target identity:100%; Query identity:100%]
Cyclic AMP phosphoprotein, 19 kD, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0015459 [potassium channel regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046326 [positive regulation of glucose import]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 112 aa
12.3 kDa 		No 0
ARPP19-009
ENSP00000457631
ENST00000563566
P56211 [Direct mapping]
cAMP-regulated phosphoprotein 19
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0015459 [potassium channel regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046326 [positive regulation of glucose import]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 96 aa
10.6 kDa 		No 0
ARPP19-010
ENSP00000455610
ENST00000569723
H3BQ52 [Direct mapping]
cAMP-regulated phosphoprotein 19
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 71 aa
7.7 kDa 		No 0
ARPP19-011
ENSP00000454612
ENST00000564163
H3BMD8 [Direct mapping]
cAMP-regulated phosphoprotein 19
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 131 aa
14.5 kDa 		No 0
ARPP19-012
ENSP00000457805
ENST00000568196
P56211 [Direct mapping]
cAMP-regulated phosphoprotein 19
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0015459 [potassium channel regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0046326 [positive regulation of glucose import]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 96 aa
10.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.