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Gene name

Class

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Chromosome

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In atlas

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ACKR4
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

ACKR4

Gene description

Atypical chemokine receptor 4

Protein class

G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (BJ hTERT+)
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

ACKR4 (HGNC Symbol)

Synonyms

CCBP2, CCR11, CCRL1, CCX-CKR, PPR1, VSHK1

Description

Atypical chemokine receptor 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]

Chromosome

3

Cytoband

q22.1

Chromosome location (bp)

132597237 - 132618967

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129048 (version 83.38)

Entrez gene

51554

UniProt

Q9NPB9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NPB9

Antibodypedia

ACKR4 antibodies

PROTEIN BROWSER

ACKR4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACKR4-001
ENSP00000249887
ENST00000249887
Q9NPB9 [Direct mapping]
Atypical chemokine receptor 4
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0019956 [chemokine binding]
GO:0055037 [recycling endosome]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
350 aa
39.9 kDa
No 7

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