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ACKR4

GENERAL INFORMATION

Gene name

 ACKR4

Gene description

 Atypical chemokine receptor 4

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (BJ hTERT+)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ACKR4 (HGNC Symbol)

Synonyms

 CCBP2, CCR11, CCRL1, CCX-CKR, PPR1, VSHK1

Description

 Atypical chemokine receptor 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]

Chromosome

 3

Cytoband

 q22.1

Chromosome location (bp)

 132597237 - 132618967

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129048 (version 83.38)

Entrez gene

 51554

UniProt

 Q9NPB9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPB9

Antibodypedia

 ACKR4 antibodies

PROTEIN BROWSER
ACKR4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACKR4-001
ENSP00000249887
ENST00000249887
Q9NPB9 [Direct mapping]
Atypical chemokine receptor 4
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0019956 [chemokine binding]
GO:0055037 [recycling endosome]
GO:0070098 [chemokine-mediated signaling pathway]
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 350 aa
39.9 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.