Expression of ANAPC13 in cancer - Summary - The Human Protein Atlas

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ANAPC13

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANAPC13
Gene description	Anaphase promoting complex subunit 13
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA046114
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), cervical cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046114

GENE INFORMATION
Gene name	ANAPC13 (HGNC Symbol)
Synonyms	APC13, DKFZP566D193, SWM1
Description	Anaphase promoting complex subunit 13 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
Chromosome	3
Cytoband	q22.2
Chromosome location (bp)	134477706 - 134486716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129055 (version 83.38)
Entrez gene	25847
UniProt	Q9BS18 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BS18
Antibodypedia	ANAPC13 antibodies

PROTEIN BROWSER

ANAPC13-001	ANAPC13-002	ANAPC13-003	ANAPC13-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANAPC13-001 ENSP00000421842 ENST00000510994	Q9BS18 [Direct mapping] Anaphase-promoting complex subunit 13 A8K3Z6 [Target identity:100%; Query identity:100%] Anaphase promoting complex subunit 13, isoform CRA_a; cDNA FLJ76550, highly similar to Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005680 [anaphase-promoting complex] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] GO:0070979 [protein K11-linked ubiquitination] Show all	74 aa 8.5 kDa	No	0
ANAPC13-002 ENSP00000421760 ENST00000511751	Q9BS18 [Direct mapping] Anaphase-promoting complex subunit 13 A8K3Z6 [Target identity:100%; Query identity:100%] Anaphase promoting complex subunit 13, isoform CRA_a; cDNA FLJ76550, highly similar to Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005680 [anaphase-promoting complex] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] GO:0070979 [protein K11-linked ubiquitination] Show all	74 aa 8.5 kDa	No	0
ANAPC13-003 ENSP00000427327 ENST00000514612	Q9BS18 [Direct mapping] Anaphase-promoting complex subunit 13 A8K3Z6 [Target identity:100%; Query identity:100%] Anaphase promoting complex subunit 13, isoform CRA_a; cDNA FLJ76550, highly similar to Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005680 [anaphase-promoting complex] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] GO:0070979 [protein K11-linked ubiquitination] Show all	74 aa 8.5 kDa	No	0
ANAPC13-004 ENSP00000346987 ENST00000354910	Q9BS18 [Direct mapping] Anaphase-promoting complex subunit 13 A8K3Z6 [Target identity:100%; Query identity:100%] Anaphase promoting complex subunit 13, isoform CRA_a; cDNA FLJ76550, highly similar to Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005680 [anaphase-promoting complex] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] GO:0070979 [protein K11-linked ubiquitination] Show all	74 aa 8.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.