Fields »
ABOUT
HELP
BLOG
COPB1

GENERAL INFORMATION

Gene name

 COPB1

Gene description

 Coatomer protein complex, subunit beta 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression often with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA043954 , HPA064403 , CAB012338
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), head and neck cancer (unfavourable) and pancreatic cancer (unfavourable).
Liver cancer p<0.001
Head and neck cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043954
HPA064403
CAB012338

GENE INFORMATION

Gene name

 COPB1 (HGNC Symbol)

Synonyms

 COPB

Description

 Coatomer protein complex, subunit beta 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

Chromosome

 11

Cytoband

 p15.2

Chromosome location (bp)

 14443440 - 14500027

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129083 (version 83.38)

Entrez gene

 1315

UniProt

 P53618 (UniProt - Evidence at protein level)

neXtProt

 NX_P53618

Antibodypedia

 COPB1 antibodies

PROTEIN BROWSER
COPB1-001
COPB1-002
COPB1-003
COPB1-004
COPB1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COPB1-001
ENSP00000249923
ENST00000249923
P53618 [Direct mapping]
Coatomer subunit beta
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005794 [Golgi apparatus]
GO:0005798 [Golgi-associated vesicle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0030126 [COPI vesicle coat]
GO:0030137 [COPI-coated vesicle]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0061024 [membrane organization]
Show all
 953 aa
107.1 kDa 		No 0
COPB1-002
ENSP00000397873
ENST00000439561
P53618 [Direct mapping]
Coatomer subunit beta
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005794 [Golgi apparatus]
GO:0005798 [Golgi-associated vesicle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0030126 [COPI vesicle coat]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0061024 [membrane organization]
Show all
 953 aa
107.1 kDa 		No 0
COPB1-003
ENSP00000436383
ENST00000534234
E9PP73 [Direct mapping]
Coatomer subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 486 aa
55.5 kDa 		No 0
COPB1-004
ENSP00000436401
ENST00000534771
E9PP63 [Direct mapping]
Coatomer subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 132 aa
15.1 kDa 		No 0
COPB1-012
ENSP00000431530
ENST00000529866
E9PKQ1 [Direct mapping]
Coatomer subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 137 aa
15.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.