Expression of SERGEF in cancer - Summary - The Human Protein Atlas

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SERGEF

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SERGEF
Gene description	Secretion regulating guanine nucleotide exchange factor
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA037811 , HPA037812
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037811	HPA037812

GENE INFORMATION
Gene name	SERGEF (HGNC Symbol)
Synonyms	DelGEF, Gnefr
Description	Secretion regulating guanine nucleotide exchange factor (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p15.1
Chromosome location (bp)	17788048 - 18013162
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129158 (version 83.38)
Entrez gene	26297
UniProt	Q9UGK8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGK8
Antibodypedia	SERGEF antibodies

PROTEIN BROWSER

SERGEF-001	SERGEF-003	SERGEF-004	SERGEF-005	SERGEF-009	SERGEF-012	SERGEF-014	SERGEF-015	SERGEF-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERGEF-001 ENSP00000265965 ENST00000265965	Q9UGK8 [Direct mapping] Secretion-regulating guanine nucleotide exchange factor Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005087 [Ran guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0045111 [intermediate filament cytoskeleton] GO:0050709 [negative regulation of protein secretion] Show all	458 aa 49 kDa	No	0
SERGEF-003 ENSP00000434188 ENST00000528200	Q9UGK8 [Direct mapping] Secretion-regulating guanine nucleotide exchange factor Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005087 [Ran guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0045111 [intermediate filament cytoskeleton] GO:0050709 [negative regulation of protein secretion] Show all	288 aa 30.6 kDa	No	0
SERGEF-004 ENSP00000437297 ENST00000529728	E9PMV6 [Direct mapping] Secretion-regulating guanine nucleotide exchange factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		229 aa 24.6 kDa	No	0
SERGEF-005 ENSP00000431314 ENST00000532265	B4DFC0 [Direct mapping] Secretion-regulating guanine nucleotide exchange factor; cDNA FLJ59192, highly similar to Secretion-regulating guanine nucleotide exchange factor Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		174 aa 18.5 kDa	No	0
SERGEF-009 ENSP00000435898 ENST00000532389	E9PS70 [Direct mapping] Secretion-regulating guanine nucleotide exchange factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 14.3 kDa	No	0
SERGEF-012 ENSP00000436080 ENST00000530613	E9PR50 [Direct mapping] Secretion-regulating guanine nucleotide exchange factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 17.5 kDa	No	0
SERGEF-014 ENSP00000436648 ENST00000525920	H0YEV5 [Direct mapping] Secretion-regulating guanine nucleotide exchange factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 11 kDa	No	0
SERGEF-015 ENSP00000436111 ENST00000529151	H0YEL8 [Direct mapping] Secretion-regulating guanine nucleotide exchange factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		299 aa 31.9 kDa	No	0
SERGEF-016 ENSP00000435003 ENST00000533241	H0YE53 [Direct mapping] Secretion-regulating guanine nucleotide exchange factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 16 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.