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TPH1

GENERAL INFORMATION

Gene name

 TPH1

Gene description

 Tryptophan hydroxylase 1

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Group enriched (colon, duodenum, rectum, small intestine, stomach)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA022483 , CAB010767
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA022483
CAB010767

GENE INFORMATION

Gene name

 TPH1 (HGNC Symbol)

Synonyms

 TPH, TPRH

Description

 Tryptophan hydroxylase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 18017564 - 18042426

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129167 (version 83.38)

Entrez gene

 7166

UniProt

 P17752 (UniProt - Evidence at protein level)

neXtProt

 NX_P17752

Antibodypedia

 TPH1 antibodies

PROTEIN BROWSER
TPH1-001
TPH1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPH1-001
ENSP00000250018
ENST00000250018
P17752 [Direct mapping]
Tryptophan 5-hydroxylase 1
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
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GO:0004497 [monooxygenase activity]
GO:0004510 [tryptophan 5-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007623 [circadian rhythm]
GO:0008152 [metabolic process]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0016597 [amino acid binding]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0030279 [negative regulation of ossification]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035902 [response to immobilization stress]
GO:0042427 [serotonin biosynthetic process]
GO:0043005 [neuron projection]
GO:0044281 [small molecule metabolic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0046219 [indolalkylamine biosynthetic process]
GO:0046849 [bone remodeling]
GO:0055114 [oxidation-reduction process]
GO:0060749 [mammary gland alveolus development]
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 444 aa
51 kDa 		No 0
TPH1-004
ENSP00000436081
ENST00000528338
E9PR49 [Direct mapping]
Tryptophan 5-hydroxylase 1
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Predicted intracellular proteins
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GO:0005506 [iron ion binding]
GO:0008152 [metabolic process]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0016597 [amino acid binding]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0055114 [oxidation-reduction process]
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 165 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.