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CSRP3

GENERAL INFORMATION

Gene name

 CSRP3

Gene description

 Cysteine and glycine-rich protein 3 (cardiac LIM protein)

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (head and neck cancer)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in heart and skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA042581
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042581

GENE INFORMATION

Gene name

 CSRP3 (HGNC Symbol)

Synonyms

 CLP, CMD1M, MLP

Description

 Cysteine and glycine-rich protein 3 (cardiac LIM protein) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 19182030 - 19210573

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129170 (version 83.38)

Entrez gene

 8048

UniProt

 P50461 (UniProt - Evidence at protein level)

neXtProt

 NX_P50461

Antibodypedia

 CSRP3 antibodies

PROTEIN BROWSER
CSRP3-002
CSRP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSRP3-002
ENSP00000431813
ENST00000533783
P50461 [Direct mapping]
Cysteine and glycine-rich protein 3
A2TDB8 [Target identity:100%; Query identity:100%]
Cysteine and glycine-rich protein 3 (Cardiac LIM protein); Cysteine and glycine-rich protein 3 (Cardiac LIM protein), isoform CRA_a; cDNA, FLJ93801, Homo sapiens cysteine and glycine-rich protein 3 (cardiac LIMprotein) (CSRP3), mRNA
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001974 [blood vessel remodeling]
GO:0002026 [regulation of the force of heart contraction]
GO:0003300 [cardiac muscle hypertrophy]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007519 [skeletal muscle tissue development]
GO:0008270 [zinc ion binding]
GO:0008307 [structural constituent of muscle]
GO:0030018 [Z disc]
GO:0031433 [telethonin binding]
GO:0033365 [protein localization to organelle]
GO:0035995 [detection of muscle stretch]
GO:0042805 [actinin binding]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048738 [cardiac muscle tissue development]
GO:0055003 [cardiac myofibril assembly]
GO:0060048 [cardiac muscle contraction]
GO:1903919 [negative regulation of actin filament severing]
GO:1903920 [positive regulation of actin filament severing]
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 194 aa
21 kDa 		No 0
CSRP3-201
ENSP00000265968
ENST00000265968
P50461 [Direct mapping]
Cysteine and glycine-rich protein 3
A2TDB8 [Target identity:100%; Query identity:100%]
Cysteine and glycine-rich protein 3 (Cardiac LIM protein); Cysteine and glycine-rich protein 3 (Cardiac LIM protein), isoform CRA_a; cDNA, FLJ93801, Homo sapiens cysteine and glycine-rich protein 3 (cardiac LIMprotein) (CSRP3), mRNA
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0003300 [cardiac muscle hypertrophy]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005856 [cytoskeleton]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007519 [skeletal muscle tissue development]
GO:0008270 [zinc ion binding]
GO:0008307 [structural constituent of muscle]
GO:0030018 [Z disc]
GO:0031433 [telethonin binding]
GO:0033365 [protein localization to organelle]
GO:0035995 [detection of muscle stretch]
GO:0042805 [actinin binding]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048738 [cardiac muscle tissue development]
GO:0055003 [cardiac myofibril assembly]
GO:0060048 [cardiac muscle contraction]
GO:1903919 [negative regulation of actin filament severing]
GO:1903920 [positive regulation of actin filament severing]
Show all
 194 aa
21 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.