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E2F8

GENERAL INFORMATION

Gene name

 E2F8

Gene description

 E2F transcription factor 8

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 E2F8 (HGNC Symbol)

Synonyms

 FLJ23311

Description

 E2F transcription factor 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 19224063 - 19241620

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129173 (version 83.38)

Entrez gene

 79733

UniProt

 A0AVK6 (UniProt - Evidence at protein level)

neXtProt

 NX_A0AVK6

Antibodypedia

 E2F8 antibodies

PROTEIN BROWSER
E2F8-001
E2F8-002
E2F8-004
E2F8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
E2F8-001
ENSP00000434199
ENST00000527884
A0AVK6 [Direct mapping]
Transcription factor E2F8
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001890 [placenta development]
GO:0002040 [sprouting angiogenesis]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0032466 [negative regulation of cytokinesis]
GO:0032877 [positive regulation of DNA endoreduplication]
GO:0033301 [cell cycle comprising mitosis without cytokinesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060718 [chorionic trophoblast cell differentiation]
GO:0070365 [hepatocyte differentiation]
Show all
 867 aa
94.2 kDa 		No 0
E2F8-002
ENSP00000250024
ENST00000250024
A0AVK6 [Direct mapping]
Transcription factor E2F8
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001890 [placenta development]
GO:0002040 [sprouting angiogenesis]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0032466 [negative regulation of cytokinesis]
GO:0032877 [positive regulation of DNA endoreduplication]
GO:0033301 [cell cycle comprising mitosis without cytokinesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060718 [chorionic trophoblast cell differentiation]
GO:0070365 [hepatocyte differentiation]
Show all
 867 aa
94.2 kDa 		No 0
E2F8-004
ENSP00000437326
ENST00000532666
E9PMT9 [Direct mapping]
Transcription factor E2F8
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 139 aa
15.7 kDa 		No 0
E2F8-201
ENSP00000481103
ENST00000620009
A0AVK6 [Direct mapping]
Transcription factor E2F8
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001890 [placenta development]
GO:0002040 [sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
GO:0032466 [negative regulation of cytokinesis]
GO:0032877 [positive regulation of DNA endoreduplication]
GO:0033301 [cell cycle comprising mitosis without cytokinesis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060718 [chorionic trophoblast cell differentiation]
GO:0070365 [hepatocyte differentiation]
Show all
 867 aa
94.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.