Expression of SHBG in cancer - Summary - The Human Protein Atlas

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SHBG

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SHBG
Gene description	Sex hormone-binding globulin
Protein class	Cancer-related genes Candidate cardiovascular disease genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	17
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (A549, AF22)
HPA (normal tissue):	Tissue enhanced (liver, testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SHBG (HGNC Symbol)
Synonyms	ABP, MGC126834, MGC138391, TEBG
Description	Sex hormone-binding globulin (HGNC Symbol)
Entrez gene summary	This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7613946 - 7633383
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129214 (version 83.38)
Entrez gene	6462
UniProt	P04278 (UniProt - Evidence at protein level)
neXtProt	NX_P04278
Antibodypedia	SHBG antibodies

PROTEIN BROWSER

SHBG-001	SHBG-002	SHBG-005	SHBG-006	SHBG-007	SHBG-008	SHBG-009	SHBG-010	SHBG-011	SHBG-012	SHBG-013	SHBG-014	SHBG-015	SHBG-016	SHBG-017	SHBG-201	SHBG-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SHBG-001 ENSP00000369816 ENST00000380450	P04278 [Direct mapping] Sex hormone-binding globulin Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005497 [androgen binding] GO:0005576 [extracellular region] GO:0070062 [extracellular exosome] Show all	402 aa 43.8 kDa	Yes	0
SHBG-002 ENSP00000388867 ENST00000416273	P04278 [Direct mapping] Sex hormone-binding globulin Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005497 [androgen binding] GO:0005576 [extracellular region] GO:0070062 [extracellular exosome] Show all	293 aa 32.4 kDa	Yes	0
SHBG-005 ENSP00000460219 ENST00000576830	A0A0C4DGN2 [Direct mapping] Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		260 aa 28.7 kDa	No	0
SHBG-006 ENSP00000458858 ENST00000571153	B0FWH5 [Direct mapping] Sex hormone binding globulin; Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		212 aa 23.4 kDa	No	0
SHBG-007 ENSP00000459826 ENST00000575618	B0FWH7 [Direct mapping] Sex hormone binding globulin; Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 12.7 kDa	No	0
SHBG-008 ENSP00000461743 ENST00000576152	B0FWH6 [Direct mapping] Sex hormone binding globulin; Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		206 aa 22.7 kDa	No	0
SHBG-009 ENSP00000458973 ENST00000575903	P04278 [Direct mapping] Sex hormone-binding globulin Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005497 [androgen binding] GO:0005576 [extracellular region] GO:0070062 [extracellular exosome] Show all	384 aa 41.7 kDa	Yes	0
SHBG-010 ENSP00000458719 ENST00000575729	I3L1C1 [Direct mapping] Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		93 aa 10.7 kDa	No	0
SHBG-011 ENSP00000458816 ENST00000572182	I3L1G4 [Direct mapping] Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		82 aa 9.5 kDa	No	0
SHBG-012 ENSP00000458181 ENST00000574539	B4DYU0 [Direct mapping] Sex hormone-binding globulin; cDNA FLJ51403, highly similar to Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		235 aa 26.1 kDa	No	0
SHBG-013 ENSP00000459620 ENST00000576728	I3L2F1 [Direct mapping] Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		181 aa 20.2 kDa	No	0
SHBG-014 ENSP00000458559 ENST00000575314	I3L145 [Direct mapping] Sex hormone-binding globulin; Sex hormone-binding globulin, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		344 aa 37.5 kDa	No	0
SHBG-015 ENSP00000458875 ENST00000570547	I3L1J1 [Direct mapping] Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		229 aa 25.4 kDa	No	0
SHBG-016 ENSP00000459999 ENST00000572262	I3L2X4 [Direct mapping] Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		290 aa 31.6 kDa	No	0
SHBG-017 ENSP00000461133 ENST00000576478	I3L4B9 [Direct mapping] Sex hormone-binding globulin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		175 aa 19.5 kDa	No	0
SHBG-201 ENSP00000345675 ENST00000340624	I3L145 [Direct mapping] Sex hormone-binding globulin; Sex hormone-binding globulin, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		344 aa 37.5 kDa	No	0
SHBG-202 ENSP00000393426 ENST00000441599	P04278 [Direct mapping] Sex hormone-binding globulin Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005497 [androgen binding] GO:0005576 [extracellular region] GO:0070062 [extracellular exosome] Show all	287 aa 31.7 kDa	Yes	0

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The Project

The Human Protein Atlas

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