Expression of TXNDC17 in cancer - Summary - The Human Protein Atlas

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TXNDC17

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TXNDC17
Gene description	Thioredoxin domain containing 17
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA022931
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022931

GENE INFORMATION
Gene name	TXNDC17 (HGNC Symbol)
Synonyms	MGC14353, TRP14, TXNL5
Description	Thioredoxin domain containing 17 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	6640758 - 6644541
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129235 (version 83.38)
Entrez gene	84817
UniProt	Q9BRA2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BRA2
Antibodypedia	TXNDC17 antibodies

PROTEIN BROWSER

TXNDC17-001	TXNDC17-006	TXNDC17-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TXNDC17-001 ENSP00000250101 ENST00000250101	Q9BRA2 [Direct mapping] Thioredoxin domain-containing protein 17 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004601 [peroxidase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0047134 [protein-disulfide reductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	123 aa 13.9 kDa	No	0
TXNDC17-006 ENSP00000460577 ENST00000574838	I3L3M7 [Direct mapping] Thioredoxin domain-containing protein 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		80 aa 9.1 kDa	No	0
TXNDC17-010 ENSP00000459868 ENST00000570330	I3L2R6 [Direct mapping] Thioredoxin domain-containing protein 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 11.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.