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ATP1B2

GENERAL INFORMATION

Gene name

 ATP1B2

Gene description

 ATPase, Na+/K+ transporting, beta 2 polypeptide

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (AF22, K-562)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in CNS

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA010698
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010698

GENE INFORMATION

Gene name

 ATP1B2 (HGNC Symbol)

Synonyms

 AMOG

Description

 ATPase, Na+/K+ transporting, beta 2 polypeptide (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7646627 - 7657768

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129244 (version 83.38)

Entrez gene

 482

UniProt

 P14415 (UniProt - Evidence at protein level)

neXtProt

 NX_P14415

Antibodypedia

 ATP1B2 antibodies

PROTEIN BROWSER
ATP1B2-001
ATP1B2-002
ATP1B2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP1B2-001
ENSP00000250111
ENST00000250111
P14415 [Direct mapping]
Sodium/potassium-transporting ATPase subunit beta-2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001671 [ATPase activator activity]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0010107 [potassium ion import]
GO:0016324 [apical plasma membrane]
GO:0030007 [cellular potassium ion homeostasis]
GO:0032781 [positive regulation of ATPase activity]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0050821 [protein stabilization]
GO:0050900 [leukocyte migration]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0086009 [membrane repolarization]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:1901018 [positive regulation of potassium ion transmembrane transporter activity]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:1903288 [positive regulation of potassium ion import]
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 290 aa
33.4 kDa 		No 1
ATP1B2-002
ENSP00000459145
ENST00000577026
I3L1V9 [Direct mapping]
Sodium/potassium-transporting ATPase subunit beta-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
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 167 aa
19.1 kDa 		No 0
ATP1B2-003
ENSP00000460499
ENST00000577113
I3L3J8 [Direct mapping]
Sodium/potassium-transporting ATPase subunit beta-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
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 172 aa
19.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.