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KIF1C

GENERAL INFORMATION

Gene name

 KIF1C

Gene description

 Kinesin family member 1C

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA024602 , HPA045020
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 KIF1C (HGNC Symbol)

Synonyms

 SAX2, SPAX2, SPG58

Description

 Kinesin family member 1C (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4997948 - 5028401

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129250 (version 83.38)

Entrez gene

 10749

UniProt

 O43896 (UniProt - Evidence at protein level)

neXtProt

 NX_O43896

Antibodypedia

 KIF1C antibodies

PROTEIN BROWSER
KIF1C-001
KIF1C-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF1C-001
ENSP00000320821
ENST00000320785
O43896 [Direct mapping]
Kinesin-like protein KIF1C
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0044822 [poly(A) RNA binding]
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 1103 aa
122.9 kDa 		No 0
KIF1C-002
ENSP00000458697
ENST00000574165
I3L1B1 [Direct mapping]
Kinesin-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed]
GO:0030705 [cytoskeleton-dependent intracellular transport]
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 138 aa
15.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.