Tissue expression of MPDU1 - Summary - The Human Protein Atlas

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MPDU1

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MPDU1
Gene description	Mannose-P-dolichol utilization defect 1
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA014845
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MPDU1 (HGNC Symbol)
Synonyms	CDGIf, Lec35, PQLC5, SL15
Description	Mannose-P-dolichol utilization defect 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an endoplasmic reticulum membrane protein that is required for utilization of the mannose donor mannose-P-dolichol in the synthesis of lipid-linked oligosaccharides and glycosylphosphatidylinositols. Mutations in this gene result in congenital disorder of glycosylation type If. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7583529 - 7592789
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129255 (version 83.38)
Entrez gene	9526
UniProt	O75352 (UniProt - Evidence at protein level)
neXtProt	NX_O75352
Antibodypedia	MPDU1 antibodies

PROTEIN BROWSER

MPDU1-001	MPDU1-006	MPDU1-022	MPDU1-024	MPDU1-025	MPDU1-026	MPDU1-028	MPDU1-029	MPDU1-201	MPDU1-202	MPDU1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPDU1-001 ENSP00000250124 ENST00000250124	O75352 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006810 [transport] GO:0009312 [oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	247 aa 26.6 kDa	No	7
MPDU1-006 ENSP00000414071 ENST00000423172	O75352 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006810 [transport] GO:0009312 [oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	186 aa 19.8 kDa	No	2
MPDU1-022 ENSP00000379758 ENST00000396501	J3QW43 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] Show all	192 aa 20.9 kDa	No	3
MPDU1-024 ENSP00000462839 ENST00000584378	J3KT75 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] Show all	154 aa 16.5 kDa	No	2
MPDU1-025 ENSP00000463037 ENST00000585217	J3KTK8 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] Show all	116 aa 12.7 kDa	No	3
MPDU1-026 ENSP00000464158 ENST00000579445	J3QRD5 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	194 aa 20.8 kDa	No	5
MPDU1-028 ENSP00000463966 ENST00000581380	J3QQZ4 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] Show all	152 aa 16.7 kDa	No	3
MPDU1-029 ENSP00000462500 ENST00000582151	J3KSI4 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.8 kDa	No	0
MPDU1-201 ENSP00000483943 ENST00000614740	Q1HDL3 [Direct mapping] HBeAg-binding protein 2 binding protein A; Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	299 aa 32 kDa	No	4
MPDU1-202 ENSP00000483915 ENST00000620608	Q9H3L2 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein; My008 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	211 aa 22.6 kDa	No	4
MPDU1-203 ENSP00000479257 ENST00000621041	A0A087WV81 [Direct mapping] Mannose-P-dolichol utilization defect 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	299 aa 32 kDa	No	4

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.