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CCNT1

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GENERAL INFORMATION

Gene name

 CCNT1

Gene description

 Cyclin T1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

siRNA

 The location(s) are Supported based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA004892 , CAB009016
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ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA004892 A-431 Nucleoplasm
HPA004892 U-2 OS Nucleoplasm
HPA004892 U-251 MG Nucleoplasm
CAB009016 A-431 Nucleoplasm
CAB009016 U-2 OS Nucleoplasm
CAB009016 U-251 MG Nucleoplasm

siRNA VALIDATION

Antibody

 HPA004892

siRNA validation

 Supported: Significant downregulation 10-25% by one/two siRNA:s

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

 84%

p-value

 < 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA004892 siRNA 1 U-2 OS
HPA004892 scrambled U-2 OS

GENE INFORMATION

Gene name

 CCNT1 (HGNC Symbol)

Synonyms

 CCNT, CYCT1, HIVE1

Description

 Cyclin T1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Chromosome

 12

Cytoband

Chromosome location (bp)

 48688458 - 48716998

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129315 (version 83.38)

Entrez gene

 904

UniProt

 O60563 (UniProt - Evidence at protein level)

neXtProt

 NX_O60563

Antibodypedia

 CCNT1 antibodies

PROTEIN BROWSER
CCNT1-001
CCNT1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNT1-001
ENSP00000261900
ENST00000261900
O60563 [Direct mapping]
Cyclin-T1
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008024 [positive transcription elongation factor complex b]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0017069 [snRNA binding]
GO:0019901 [protein kinase binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]
GO:0051301 [cell division]
GO:1900364 [negative regulation of mRNA polyadenylation]
GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
Show all
 726 aa
80.7 kDa 		No 0
CCNT1-201
ENSP00000481035
ENST00000618666
O60563 [Direct mapping]
Cyclin-T1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008024 [positive transcription elongation factor complex b]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]
GO:0051301 [cell division]
GO:1900364 [negative regulation of mRNA polyadenylation]
GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
Show all
 184 aa
21.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.