Expression of PUS7L in cancer - Summary - The Human Protein Atlas

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PUS7L

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PUS7L
Gene description	Pseudouridylate synthase 7-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA056203 , HPA058750
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056203	HPA058750

GENE INFORMATION
Gene name	PUS7L (HGNC Symbol)
Synonyms	DKFZP434G1415
Description	Pseudouridylate synthase 7-like (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q12
Chromosome location (bp)	43718993 - 43758817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129317 (version 83.38)
Entrez gene	83448
UniProt	Q9H0K6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0K6
Antibodypedia	PUS7L antibodies

PROTEIN BROWSER

PUS7L-001	PUS7L-002	PUS7L-004	PUS7L-005	PUS7L-007	PUS7L-008	PUS7L-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PUS7L-001 ENSP00000343081 ENST00000344862	Q9H0K6 [Direct mapping] Pseudouridylate synthase 7 homolog-like protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	701 aa 80.7 kDa	No	0
PUS7L-002 ENSP00000447706 ENST00000551923	Q9H0K6 [Direct mapping] Pseudouridylate synthase 7 homolog-like protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	701 aa 80.7 kDa	No	0
PUS7L-004 ENSP00000415899 ENST00000416848	Q9H0K6 [Direct mapping] Pseudouridylate synthase 7 homolog-like protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	701 aa 80.7 kDa	No	0
PUS7L-005 ENSP00000398497 ENST00000431332	Q9H0K6 [Direct mapping] Pseudouridylate synthase 7 homolog-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	388 aa 44.7 kDa	No	0
PUS7L-007 ENSP00000449502 ENST00000549868	F8VWC0 [Direct mapping] Pseudouridylate synthase 7 homolog-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	126 aa 14.4 kDa	No	0
PUS7L-008 ENSP00000449222 ENST00000550784	F8VW99 [Direct mapping] Pseudouridylate synthase 7 homolog-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	161 aa 18.5 kDa	No	0
PUS7L-009 ENSP00000450341 ENST00000547156	F8VP66 [Direct mapping] Pseudouridylate synthase 7 homolog-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	154 aa 17.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.