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ILF3

GENERAL INFORMATION

Gene name

 ILF3

Gene description

 Interleukin enhancer binding factor 3, 90kDa

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA001897
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ILF3 (HGNC Symbol)

Synonyms

 DRBP76, MPHOSPH4, MPP4, NF90, NFAR-1

Description

 Interleukin enhancer binding factor 3, 90kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10654261 - 10692417

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129351 (version 83.38)

Entrez gene

 3609

UniProt

 Q12906 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12906

Antibodypedia

 ILF3 antibodies

PROTEIN BROWSER
«
ILF3-001
ILF3-002
ILF3-003
ILF3-004
ILF3-005
ILF3-006
ILF3-013
ILF3-014
ILF3-015
ILF3-016
ILF3-017
ILF3-022
ILF3-023
ILF3-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ILF3-001
ENSP00000384660
ENST00000407004
Q12906 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051607 [defense response to virus]
Show all
 706 aa
76.5 kDa 		No 0
ILF3-002
ENSP00000465219
ENST00000589998
Q12906 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051607 [defense response to virus]
Show all
 702 aa
76 kDa 		No 0
ILF3-003
ENSP00000250241
ENST00000250241
Q12906 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051607 [defense response to virus]
Show all
 690 aa
74.6 kDa 		No 0
ILF3-004
ENSP00000465515
ENST00000592763
Q12906 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051607 [defense response to virus]
Show all
 698 aa
75.5 kDa 		No 0
ILF3-005
ENSP00000468156
ENST00000590261
Q12906 [Direct mapping]
Interleukin enhancer-binding factor 3
A0A024R7C7 [Target identity:100%; Query identity:100%]
Interleukin enhancer binding factor 3, 90kDa, isoform CRA_d
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051607 [defense response to virus]
Show all
 894 aa
95.3 kDa 		No 0
ILF3-006
ENSP00000468181
ENST00000588657
Q12906 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051607 [defense response to virus]
Show all
 898 aa
95.8 kDa 		No 0
ILF3-013
ENSP00000468323
ENST00000593199
K7ERM6 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 78 aa
8.8 kDa 		No 0
ILF3-014
ENSP00000465654
ENST00000590009
K7EKJ9 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
Show all
 254 aa
28.3 kDa 		No 0
ILF3-015
ENSP00000466396
ENST00000589283
K7EM82 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 99 aa
11.2 kDa 		No 0
ILF3-016
ENSP00000468134
ENST00000589600
K7ER69 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
Show all
 161 aa
17.9 kDa 		No 0
ILF3-017
ENSP00000464974
ENST00000587941
K7EJ09 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 122 aa
13.6 kDa 		No 0
ILF3-022
ENSP00000466724
ENST00000593061
K7EMZ8 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 113 aa
11.7 kDa 		No 0
ILF3-023
ENSP00000466235
ENST00000590869
K7ELV3 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 116 aa
11.3 kDa 		No 0
ILF3-201
ENSP00000404121
ENST00000449870
Q12906 [Direct mapping]
Interleukin enhancer-binding factor 3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051607 [defense response to virus]
Show all
 898 aa
95.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.