Expression of KLK14 in cancer - Summary - The Human Protein Atlas

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KLK14

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KLK14
Gene description	Kallikrein-related peptidase 14
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (HaCaT, U-266/84)
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular deposits and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. CAB026228
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB026228

GENE INFORMATION
Gene name	KLK14 (HGNC Symbol)
Synonyms	KLK-L6
Description	Kallikrein-related peptidase 14 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	51077495 - 51084245
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129437 (version 83.38)
Entrez gene	43847
UniProt	Q9P0G3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P0G3
Antibodypedia	KLK14 antibodies

PROTEIN BROWSER

KLK14-001	KLK14-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLK14-001 ENSP00000156499 ENST00000156499	Q9P0G3 [Direct mapping] Kallikrein-14 A0A024R4M6 [Target identity:100%; Query identity:100%] Kallikrein 14, isoform CRA_a Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0009566 [fertilization] GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway] GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway] GO:0048730 [epidermis morphogenesis] GO:0070062 [extracellular exosome] GO:0070684 [seminal clot liquefaction] Show all	267 aa 29.1 kDa	Yes	0
KLK14-201 ENSP00000375678 ENST00000391802	Q9P0G3 [Direct mapping] Kallikrein-14 A0A024R4M6 [Target identity:100%; Query identity:100%] Kallikrein 14, isoform CRA_a Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0009566 [fertilization] GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway] GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway] GO:0048730 [epidermis morphogenesis] GO:0070062 [extracellular exosome] GO:0070684 [seminal clot liquefaction] Show all	267 aa 29.1 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.