Tissue expression of KLK10 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KLK10
Gene description	Kallikrein-related peptidase 10
Protein class	Cancer-related genes Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (esophagus, skin)
GTEx:	Tissue enhanced (esophagus, vagina)
FANTOM5:	Group enriched (cervix, uterine, esophagus, gallbladder, tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, vagina)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cervix, uterine, esophagus, gallbladder, tonsil)

GENE INFORMATION
Gene name	KLK10 (HGNC Symbol)
Synonyms	NES1, PRSSL1
Description	Kallikrein-related peptidase 10 (HGNC Symbol)
Entrez gene summary	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	51012739 - 51020175
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129451 (version 83.38)
Entrez gene	5655
UniProt	O43240 (UniProt - Evidence at protein level)
neXtProt	NX_O43240
Antibodypedia	KLK10 antibodies

PROTEIN BROWSER

KLK10-001	KLK10-002	KLK10-004	KLK10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLK10-001 ENSP00000311746 ENST00000309958	O43240 [Direct mapping] Kallikrein-10 Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0007049 [cell cycle] GO:0008236 [serine-type peptidase activity] Show all	276 aa 30.2 kDa	Yes	0
KLK10-002 ENSP00000351640 ENST00000358789	O43240 [Direct mapping] Kallikrein-10 Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0007049 [cell cycle] GO:0008236 [serine-type peptidase activity] Show all	276 aa 30.2 kDa	Yes	0
KLK10-004 ENSP00000471610 ENST00000599077	M0R132 [Direct mapping] Kallikrein-10 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	143 aa 15.7 kDa	Yes	0
KLK10-201 ENSP00000375681 ENST00000391805	O43240 [Direct mapping] Kallikrein-10 Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0007049 [cell cycle] GO:0008236 [serine-type peptidase activity] Show all	276 aa 30.2 kDa	Yes	0