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The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001914 [regulation of T cell mediated cytotoxicity] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0002819 [regulation of adaptive immune response] GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004704 [NF-kappaB-inducing kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0010922 [positive regulation of phosphatase activity] GO:0012501 [programmed cell death] GO:0032147 [activation of protein kinase activity] GO:0032403 [protein complex binding] GO:0032481 [positive regulation of type I interferon production] GO:0032649 [regulation of interferon-gamma production] GO:0033077 [T cell differentiation in thymus] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038061 [NIK/NF-kappaB signaling] GO:0042802 [identical protein binding] GO:0043029 [T cell homeostasis] GO:0045087 [innate immune response] GO:0046006 [regulation of activated T cell proliferation] GO:0046777 [protein autophosphorylation] GO:0048535 [lymph node development] GO:0048536 [spleen development] GO:0048538 [thymus development] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051260 [protein homooligomerization] GO:0051291 [protein heterooligomerization] GO:0051351 [positive regulation of ligase activity] GO:0051353 [positive regulation of oxidoreductase activity] GO:0060545 [positive regulation of necroptotic process] GO:0070235 [regulation of activation-induced cell death of T cells] GO:0070266 [necroptotic process] GO:0090312 [positive regulation of protein deacetylation] GO:0097190 [apoptotic signaling pathway] GO:0097300 [programmed necrotic cell death] GO:0097342 [ripoptosome] GO:1990000 [amyloid fibril formation] GO:2000377 [regulation of reactive oxygen species metabolic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2000452 [regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]