Expression of ADCY4 in cancer - Summary - The Human Protein Atlas

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ADCY4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADCY4
Gene description	Adenylate cyclase 4
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (HUVEC TERT2, TIME)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA048344 , CAB005070
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048344	CAB005070

GENE INFORMATION
Gene name	ADCY4 (HGNC Symbol)
Synonyms	AC4
Description	Adenylate cyclase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24318349 - 24335093
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129467 (version 83.38)
Entrez gene	196883
UniProt	Q8NFM4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFM4
Antibodypedia	ADCY4 antibodies

PROTEIN BROWSER

ADCY4-001	ADCY4-002	ADCY4-006	ADCY4-011	ADCY4-016	ADCY4-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADCY4-001 ENSP00000312126 ENST00000310677	Q8NFM4 [Direct mapping] Adenylate cyclase type 4 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0003091 [renal water homeostasis] GO:0004016 [adenylate cyclase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006171 [cAMP biosynthetic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016849 [phosphorus-oxygen lyase activity] GO:0019933 [cAMP-mediated signaling] GO:0030425 [dendrite] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0034199 [activation of protein kinase A activity] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] Show all	1077 aa 119.8 kDa	No	>9
ADCY4-002 ENSP00000452250 ENST00000554068	Q8NFM4 [Direct mapping] Adenylate cyclase type 4 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0003091 [renal water homeostasis] GO:0004016 [adenylate cyclase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006171 [cAMP biosynthetic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016849 [phosphorus-oxygen lyase activity] GO:0019933 [cAMP-mediated signaling] GO:0034199 [activation of protein kinase A activity] GO:0035556 [intracellular signal transduction] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] Show all	1077 aa 119.8 kDa	No	>9
ADCY4-006 ENSP00000393177 ENST00000418030	Q8NFM4 [Direct mapping] Adenylate cyclase type 4 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0003091 [renal water homeostasis] GO:0004016 [adenylate cyclase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006171 [cAMP biosynthetic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016849 [phosphorus-oxygen lyase activity] GO:0019933 [cAMP-mediated signaling] GO:0034199 [activation of protein kinase A activity] GO:0035556 [intracellular signal transduction] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] Show all	1077 aa 119.8 kDa	No	>9
ADCY4-011 ENSP00000450843 ENST00000556932	H0YJ57 [Direct mapping] Adenylate cyclase type 4 Show all	Predicted intracellular proteins Show all	GO:0004016 [adenylate cyclase activity] GO:0005886 [plasma membrane] GO:0006171 [cAMP biosynthetic process] Show all	137 aa 15 kDa	No	0
ADCY4-016 ENSP00000453893 ENST00000561138	H0YN72 [Direct mapping] Adenylate cyclase type 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	115 aa 12.5 kDa	No	2
ADCY4-019 ENSP00000453259 ENST00000559167	H0YLM0 [Direct mapping] Adenylate cyclase type 4 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		36 aa 3.7 kDa	No	0

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