Expression of BCL2L2 in cancer - Summary - The Human Protein Atlas

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BCL2L2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BCL2L2
Gene description	BCL2-like 2
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB040539
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

CAB040539

GENE INFORMATION
Gene name	BCL2L2 (HGNC Symbol)
Synonyms	BCL-W, KIAA0271, PPP1R51
Description	BCL2-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	23298790 - 23311759
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129473 (version 83.38)
Entrez gene	599
UniProt	Q92843 (UniProt - Evidence at protein level)
neXtProt	NX_Q92843
Antibodypedia	BCL2L2 antibodies

PROTEIN BROWSER

BCL2L2-001	BCL2L2-002	BCL2L2-003	BCL2L2-004	BCL2L2-005	BCL2L2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL2L2-001 ENSP00000250405 ENST00000250405	Q92843 [Direct mapping] Bcl-2-like protein 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0007283 [spermatogenesis] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0031966 [mitochondrial membrane] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051400 [BH domain binding] GO:0060011 [Sertoli cell proliferation] GO:0070062 [extracellular exosome] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	193 aa 20.7 kDa	No	2
BCL2L2-002 ENSP00000451148 ENST00000553824	G3V3B7 [Direct mapping] Bcl-2-like protein 2 Show all	Predicted intracellular proteins Show all	GO:0005741 [mitochondrial outer membrane] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	51 aa 5.2 kDa	No	0
BCL2L2-003 ENSP00000451701 ENST00000557236	G3V4B7 [Direct mapping] Bcl-2-like protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005741 [mitochondrial outer membrane] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	149 aa 16.2 kDa	No	0
BCL2L2-004 ENSP00000452265 ENST00000557579	G3V5A9 [Direct mapping] Bcl-2-like protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005741 [mitochondrial outer membrane] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	144 aa 15.7 kDa	No	0
BCL2L2-005 ENSP00000451234 ENST00000554635	G3V3G8 [Direct mapping] Bcl-2-like protein 2 Show all	Predicted intracellular proteins Show all	GO:0005741 [mitochondrial outer membrane] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	72 aa 7.7 kDa	No	0
BCL2L2-006 ENSP00000451197 ENST00000556599	H0YJC7 [Direct mapping] Bcl-2-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005741 [mitochondrial outer membrane] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016021 [integral component of membrane] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	167 aa 18.1 kDa	No	2

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