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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDO1
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CDO1

Gene description

Cysteine dioxygenase type 1

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (glioma, liver cancer)
HPA (cell line):Cell line enhanced (AF22, ASC TERT1, NTERA-2)
HPA (normal tissue):Tissue enhanced (epididymis, liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in liver

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA057503
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (glioma, liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA057503

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas along with a single case each of carcinoid, squamous cell carcinoma of lung and urothelial cancer showed moderate cytoplasmic staining. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

CDO1

Synonyms

Description

Cysteine dioxygenase type 1 (HGNC Symbol)

Entrez gene summary

Chromosome

5

Cytoband

q22.3

Chromosome location (bp)

115804733 - 115816954

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129596 (version 83.38)

Entrez gene

1036

UniProt

Q16878 (UniProt - Evidence at protein level)

neXtProt

NX_Q16878

Antibodypedia

CDO1 antibodies

PROTEIN BROWSER

CDO1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDO1-001
ENSP00000250535
ENST00000250535
Q16878 [Direct mapping]
Cysteine dioxygenase type 1
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0000097 [sulfur amino acid biosynthetic process]
GO:0000098 [sulfur amino acid catabolic process]
GO:0005506 [iron ion binding]
GO:0005829 [cytosol]
GO:0006534 [cysteine metabolic process]
GO:0006954 [inflammatory response]
GO:0007595 [lactation]
GO:0008198 [ferrous iron binding]
GO:0010243 [response to organonitrogen compound]
GO:0017172 [cysteine dioxygenase activity]
GO:0019448 [L-cysteine catabolic process]
GO:0033762 [response to glucagon]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042412 [taurine biosynthetic process]
GO:0043200 [response to amino acid]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0046439 [L-cysteine metabolic process]
GO:0051384 [response to glucocorticoid]
GO:0051591 [response to cAMP]
GO:0055114 [oxidation-reduction process]
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200 aa
23 kDa
No 0

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