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ASH2L

GENERAL INFORMATION

Gene name

 ASH2L

Gene description

 Ash2 (absent, small, or homeotic)-like (Drosophila)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly nuclear expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA042289
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ASH2L (HGNC Symbol)

Synonyms

 ASH2, ASH2L1, ASH2L2, Bre2

Description

 Ash2 (absent, small, or homeotic)-like (Drosophila) (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 p11.23

Chromosome location (bp)

 38105242 - 38144076

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129691 (version 83.38)

Entrez gene

 9070

UniProt

 Q9UBL3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBL3

Antibodypedia

 ASH2L antibodies

PROTEIN BROWSER
ASH2L-001
ASH2L-002
ASH2L-003
ASH2L-006
ASH2L-011
ASH2L-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASH2L-001
ENSP00000340896
ENST00000343823
Q9UBL3 [Direct mapping]
Set1/Ash2 histone methyltransferase complex subunit ASH2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008013 [beta-catenin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0030097 [hemopoiesis]
GO:0035097 [histone methyltransferase complex]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043627 [response to estrogen]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048188 [Set1C/COMPASS complex]
GO:0051568 [histone H3-K4 methylation]
GO:1990188 [euchromatin binding]
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 628 aa
68.7 kDa 		No 0
ASH2L-002
ENSP00000395310
ENST00000428278
Q9UBL3 [Direct mapping]
Set1/Ash2 histone methyltransferase complex subunit ASH2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008013 [beta-catenin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0030097 [hemopoiesis]
GO:0035097 [histone methyltransferase complex]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043627 [response to estrogen]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
GO:0048188 [Set1C/COMPASS complex]
GO:0051568 [histone H3-K4 methylation]
Show all
 534 aa
60.2 kDa 		No 0
ASH2L-003
ENSP00000430259
ENST00000521652
Q9UBL3 [Direct mapping]
Set1/Ash2 histone methyltransferase complex subunit ASH2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008013 [beta-catenin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0030097 [hemopoiesis]
GO:0035097 [histone methyltransferase complex]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0043627 [response to estrogen]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
GO:0048188 [Set1C/COMPASS complex]
GO:0051568 [histone H3-K4 methylation]
Show all
 501 aa
56.5 kDa 		No 0
ASH2L-006
ENSP00000428877
ENST00000517719
E5RFH5 [Direct mapping]
Set1/Ash2 histone methyltransferase complex subunit ASH2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 201 aa
20.7 kDa 		No 0
ASH2L-011
ENSP00000429387
ENST00000524247
H0YBF6 [Direct mapping]
Set1/Ash2 histone methyltransferase complex subunit ASH2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 192 aa
21.7 kDa 		No 0
ASH2L-201
ENSP00000443606
ENST00000545394
F5H8F7 [Direct mapping]
Set1/Ash2 histone methyltransferase complex subunit ASH2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 489 aa
55.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.