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CDKN1C

GENERAL INFORMATION

Gene name

 CDKN1C

Gene description

 Cyclin-dependent kinase inhibitor 1C (p57, Kip2)

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (placenta)
GTEx:Expressed in all
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in placenta and a subset of tissues including adrenal gland and glomeruli in kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA002924
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 CDKN1C (HGNC Symbol)

Synonyms

 BWCR, BWS, KIP2, P57

Description

 Cyclin-dependent kinase inhibitor 1C (p57, Kip2) (HGNC Symbol)

Entrez gene summary

 This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 2883213 - 2885881

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129757 (version 83.38)

Entrez gene

 1028

UniProt

 P49918 (UniProt - Evidence at protein level)

neXtProt

 NX_P49918

Antibodypedia

 CDKN1C antibodies

PROTEIN BROWSER
CDKN1C-001
CDKN1C-002
CDKN1C-003
CDKN1C-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDKN1C-001
ENSP00000413720
ENST00000414822
P49918 [Direct mapping]
Cyclin-dependent kinase inhibitor 1C
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0001822 [kidney development]
GO:0001890 [placenta development]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007050 [cell cycle arrest]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007568 [aging]
GO:0030099 [myeloid cell differentiation]
GO:0030325 [adrenal gland development]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0033673 [negative regulation of kinase activity]
GO:0035264 [multicellular organism growth]
GO:0042326 [negative regulation of phosphorylation]
GO:0042551 [neuron maturation]
GO:0043010 [camera-type eye development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0055123 [digestive system development]
GO:0060065 [uterus development]
GO:0060669 [embryonic placenta morphogenesis]
GO:0071514 [genetic imprinting]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 316 aa
32.2 kDa 		No 0
CDKN1C-002
ENSP00000370101
ENST00000380725
A6NK88 [Direct mapping]
Cyclin-dependent kinase inhibitor 1C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0007050 [cell cycle arrest]
GO:0007346 [regulation of mitotic cell cycle]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
 131 aa
15.1 kDa 		No 0
CDKN1C-003
ENSP00000411257
ENST00000440480
P49918 [Direct mapping]
Cyclin-dependent kinase inhibitor 1C
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007050 [cell cycle arrest]
GO:0007346 [regulation of mitotic cell cycle]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0033673 [negative regulation of kinase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 305 aa
31 kDa 		No 0
CDKN1C-006
ENSP00000411552
ENST00000430149
P49918 [Direct mapping]
Cyclin-dependent kinase inhibitor 1C
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007050 [cell cycle arrest]
GO:0007346 [regulation of mitotic cell cycle]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0033673 [negative regulation of kinase activity]
GO:0042326 [negative regulation of phosphorylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 316 aa
32.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.