Expression of CBFA2T3 in cancer - Summary - The Human Protein Atlas

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CBFA2T3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CBFA2T3
Gene description	Core-binding factor, runt domain, alpha subunit 2; translocated to, 3
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL, K-562, REH)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA065890
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065890

GENE INFORMATION
Gene name	CBFA2T3 (HGNC Symbol)
Synonyms	MTG16, MTGR2, ZMYND4
Description	Core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	88874858 - 88977204
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129993 (version 83.38)
Entrez gene	863
UniProt	O75081 (UniProt - Evidence at protein level)
neXtProt	NX_O75081
Antibodypedia	CBFA2T3 antibodies

PROTEIN BROWSER

CBFA2T3-001	CBFA2T3-002	CBFA2T3-006	CBFA2T3-008	CBFA2T3-009	CBFA2T3-010	CBFA2T3-011	CBFA2T3-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CBFA2T3-001 ENSP00000268679 ENST00000268679	O75081 [Direct mapping] Protein CBFA2T3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000139 [Golgi membrane] GO:0001666 [response to hypoxia] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008283 [cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0030851 [granulocyte differentiation] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0045820 [negative regulation of glycolytic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:1903715 [regulation of aerobic respiration] Show all	653 aa 71.2 kDa	No	0
CBFA2T3-002 ENSP00000332122 ENST00000327483	O75081 [Direct mapping] Protein CBFA2T3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001666 [response to hypoxia] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008283 [cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0030851 [granulocyte differentiation] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0045820 [negative regulation of glycolytic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:1903715 [regulation of aerobic respiration] Show all	567 aa 62.4 kDa	No	0
CBFA2T3-006 ENSP00000454851 ENST00000569464	H3BNH2 [Direct mapping] Protein CBFA2T3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	419 aa 46.7 kDa	No	0
CBFA2T3-008 ENSP00000456717 ENST00000562719	H3BSI4 [Direct mapping] Protein CBFA2T3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	132 aa 13.8 kDa	No	0
CBFA2T3-009 ENSP00000454872 ENST00000563640	H3BNI7 [Direct mapping] Protein CBFA2T3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	130 aa 12.9 kDa	No	0
CBFA2T3-010 ENSP00000457410 ENST00000569443	H3BU07 [Direct mapping] Protein CBFA2T3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	121 aa 12.5 kDa	No	0
CBFA2T3-011 ENSP00000454609 ENST00000564416	H3BMZ0 [Direct mapping] Protein CBFA2T3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	62 aa 6.7 kDa	No	0
CBFA2T3-012 ENSP00000456102 ENST00000570046	H3BR72 [Direct mapping] Protein CBFA2T3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	22 aa 2.3 kDa	No	0

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