Expression of NXNL2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NXNL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NXNL2
Gene description	Nucleoredoxin-like 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, endometrial cancer, ovarian cancer, renal cancer)
HPA (cell line):	Cell line enhanced (RPTEC TERT1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA045526
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), breast cancer (favourable) and renal cancer (favourable).
Endometrial cancer p<0.001 Breast cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, endometrial cancer, ovarian cancer, renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045526

GENE INFORMATION
Gene name	NXNL2 (HGNC Symbol)
Synonyms	C9orf121
Description	Nucleoredoxin-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q22.1
Chromosome location (bp)	88535101 - 88584274
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000130045 (version 83.38)
Entrez gene	158046
UniProt	Q5VZ03 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VZ03
Antibodypedia	NXNL2 antibodies

PROTEIN BROWSER

NXNL2-003	NXNL2-201	NXNL2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NXNL2-003 ENSP00000365015 ENST00000375855	Q5VZ03 [Direct mapping] Nucleoredoxin-like protein 2 Show all	Predicted intracellular proteins Show all	GO:0045494 [photoreceptor cell maintenance] Show all	135 aa 14.7 kDa	No	0
NXNL2-201 ENSP00000365014 ENST00000375854	Q5VZ03 [Direct mapping] Nucleoredoxin-like protein 2 Show all	Predicted intracellular proteins Show all	GO:0007601 [visual perception] GO:0007608 [sensory perception of smell] GO:0045494 [photoreceptor cell maintenance] Show all	156 aa 17.6 kDa	No	0
NXNL2-202 ENSP00000480855 ENST00000618633	A0A087WXA5 [Direct mapping] Nucleoredoxin-like protein 2 Show all	Predicted intracellular proteins Show all	GO:0007600 [sensory perception] GO:0045494 [photoreceptor cell maintenance] Show all	135 aa 14.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.