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SAT1

GENERAL INFORMATION

Gene name

 SAT1

Gene description

 Spermidine/spermine N1-acetyltransferase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA055312 , CAB047343
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055312
CAB047343

GENE INFORMATION

Gene name

 SAT1 (HGNC Symbol)

Synonyms

 SAT, SSAT

Description

 Spermidine/spermine N1-acetyltransferase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

Chromosome

 X

Cytoband

 p22.11

Chromosome location (bp)

 23783173 - 23786226

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130066 (version 83.38)

Entrez gene

 6303

UniProt

 P21673 (UniProt - Evidence at protein level)

neXtProt

 NX_P21673

Antibodypedia

 SAT1 antibodies

PROTEIN BROWSER
SAT1-001
SAT1-003
SAT1-004
SAT1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SAT1-001
ENSP00000368572
ENST00000379270
P21673 [Direct mapping]
Diamine acetyltransferase 1
Q6ICU9 [Target identity:100%; Query identity:100%]
SAT protein; Spermidine/spermine N1-acetyltransferase, isoform CRA_b; cDNA, FLJ92448, Homo sapiens spermidine/spermine N1-acetyltransferase (SAT), mRNA
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
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GO:0001525 [angiogenesis]
GO:0004145 [diamine N-acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006595 [polyamine metabolic process]
GO:0006596 [polyamine biosynthetic process]
GO:0008080 [N-acetyltransferase activity]
GO:0009447 [putrescine catabolic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042127 [regulation of cell proliferation]
GO:0044281 [small molecule metabolic process]
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 171 aa
20 kDa 		No 0
SAT1-003
ENSP00000368555
ENST00000379253
A6NM56 [Direct mapping]
Diamine acetyltransferase 1
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Predicted intracellular proteins
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 120 aa
13.8 kDa 		No 0
SAT1-004
ENSP00000368553
ENST00000379251
A6NJE6 [Direct mapping]
Diamine acetyltransferase 1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
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 150 aa
16.8 kDa 		No 0
SAT1-005
ENSP00000368556
ENST00000379254
E9PD37 [Direct mapping]
Diamine acetyltransferase 1
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Predicted intracellular proteins
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GO:0008080 [N-acetyltransferase activity]
GO:0008152 [metabolic process]
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 143 aa
16.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.