Expression of PRKCSH in cancer - Summary - The Human Protein Atlas

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PRKCSH

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRKCSH
Gene description	Protein kinase C substrate 80K-H
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA041940 , HPA043560 , CAB004465
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041940	HPA043560	CAB004465

GENE INFORMATION
Gene name	PRKCSH (HGNC Symbol)
Synonyms	G19P1, PCLD, PLD1
Description	Protein kinase C substrate 80K-H (HGNC Symbol)
Entrez gene summary	This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	11435288 - 11450968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130175 (version 83.38)
Entrez gene	5589
UniProt	P14314 (UniProt - Evidence at protein level)
neXtProt	NX_P14314
Antibodypedia	PRKCSH antibodies

PROTEIN BROWSER

PRKCSH-001	PRKCSH-002	PRKCSH-003	PRKCSH-005	PRKCSH-007	PRKCSH-010	PRKCSH-016	PRKCSH-017	PRKCSH-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRKCSH-001 ENSP00000465461 ENST00000589838	P14314 [Direct mapping] Glucosidase 2 subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005080 [protein kinase C binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006457 [protein folding] GO:0006491 [N-glycan processing] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0035556 [intracellular signal transduction] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0051219 [phosphoprotein binding] Show all	528 aa 59.4 kDa	Yes	0
PRKCSH-002 ENSP00000465489 ENST00000591462	P14314 [Direct mapping] Glucosidase 2 subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005080 [protein kinase C binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006457 [protein folding] GO:0006491 [N-glycan processing] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0035556 [intracellular signal transduction] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0051219 [phosphoprotein binding] Show all	525 aa 59.2 kDa	Yes	0
PRKCSH-003 ENSP00000466134 ENST00000592741	K7ELL7 [Direct mapping] Glucosidase 2 subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0001889 [liver development] GO:0003723 [RNA binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006491 [N-glycan processing] GO:0006807 [nitrogen compound metabolic process] GO:0010977 [negative regulation of neuron projection development] GO:0051291 [protein heterooligomerization] GO:0072001 [renal system development] Show all	535 aa 60.2 kDa	Yes	0
PRKCSH-005 ENSP00000466012 ENST00000587327	P14314 [Direct mapping] Glucosidase 2 subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005080 [protein kinase C binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006457 [protein folding] GO:0006491 [N-glycan processing] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0035556 [intracellular signal transduction] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0051219 [phosphoprotein binding] Show all	525 aa 59.2 kDa	Yes	0
PRKCSH-007 ENSP00000465889 ENST00000588269	K7EL27 [Direct mapping] Glucosidase 2 subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006491 [N-glycan processing] Show all	132 aa 14.3 kDa	Yes	0
PRKCSH-010 ENSP00000464835 ENST00000591946	K7EIP3 [Direct mapping] Glucosidase 2 subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006491 [N-glycan processing] Show all	62 aa 7 kDa	Yes	0
PRKCSH-016 ENSP00000467566 ENST00000589126	K7EPW7 [Direct mapping] Glucosidase 2 subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006491 [N-glycan processing] Show all	168 aa 19 kDa	Yes	0
PRKCSH-017 ENSP00000465821 ENST00000587509	K7EKX1 [Direct mapping] Glucosidase 2 subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006491 [N-glycan processing] Show all	140 aa 15.6 kDa	Yes	0
PRKCSH-018 ENSP00000465047 ENST00000593101	K7EJ70 [Direct mapping] Glucosidase 2 subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006491 [N-glycan processing] Show all	144 aa 16.1 kDa	Yes	0

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