Expression of CNN1 in cancer - Summary - The Human Protein Atlas

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CNN1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CNN1
Gene description	Calponin 1, basic, smooth muscle
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HBF TERT88)
HPA (normal tissue):	Tissue enhanced (seminal vesicle, smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly selective cytoplasmic expression in smooth muscle and myoepithelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA014263 , CAB000007
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014263	CAB000007

GENE INFORMATION
Gene name	CNN1 (HGNC Symbol)
Synonyms	Sm-Calp, SMCC
Description	Calponin 1, basic, smooth muscle (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	11538717 - 11550323
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130176 (version 83.38)
Entrez gene	1264
UniProt	P51911 (UniProt - Evidence at protein level)
neXtProt	NX_P51911
Antibodypedia	CNN1 antibodies

PROTEIN BROWSER

CNN1-001	CNN1-002	CNN1-003	CNN1-004	CNN1-005	CNN1-007	CNN1-008	CNN1-009	CNN1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNN1-001 ENSP00000252456 ENST00000252456	P51911 [Direct mapping] Calponin-1 V9HWA5 [Target identity:100%; Query identity:100%] Calponin Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0006940 [regulation of smooth muscle contraction] GO:0031032 [actomyosin structure organization] Show all	297 aa 33.2 kDa	No	0
CNN1-002 ENSP00000468259 ENST00000592923	B7Z7E1 [Direct mapping] Calponin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0031032 [actomyosin structure organization] Show all	247 aa 27.4 kDa	No	0
CNN1-003 ENSP00000442031 ENST00000535659	B7Z7E1 [Direct mapping] Calponin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0031032 [actomyosin structure organization] Show all	247 aa 27.4 kDa	No	0
CNN1-004 ENSP00000466886 ENST00000586059	K7ENC5 [Direct mapping] Calponin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0031032 [actomyosin structure organization] Show all	116 aa 13.1 kDa	No	0
CNN1-005 ENSP00000468326 ENST00000585869	K7ERM8 [Direct mapping] Calponin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	120 aa 14.1 kDa	No	0
CNN1-007 ENSP00000468053 ENST00000588935	K7ER02 [Direct mapping] Calponin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0031032 [actomyosin structure organization] Show all	228 aa 25 kDa	No	0
CNN1-008 ENSP00000467701 ENST00000586577	K7EQ72 [Direct mapping] Calponin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0031032 [actomyosin structure organization] Show all	173 aa 19.1 kDa	No	0
CNN1-009 ENSP00000468737 ENST00000587087	K7ESJ2 [Direct mapping] Calponin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	115 aa 13 kDa	No	0
CNN1-010 ENSP00000468293 ENST00000592338	K7ERK4 [Direct mapping] Transgelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	175 aa 19.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.