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CDC16

GENERAL INFORMATION

Gene name

 CDC16

Gene description

 Cell division cycle 16

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA042826
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA042826

GENE INFORMATION

Gene name

 CDC16 (HGNC Symbol)

Synonyms

 ANAPC6, APC6, CUT9

Description

 Cell division cycle 16 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q34

Chromosome location (bp)

 114234887 - 114272723

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130177 (version 83.38)

Entrez gene

 8881

UniProt

 Q13042 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13042

Antibodypedia

 CDC16 antibodies

PROTEIN BROWSER
CDC16-001
CDC16-006
CDC16-007
CDC16-008
CDC16-009
CDC16-201
CDC16-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC16-001
ENSP00000252458
ENST00000252458
Q5T8C6 [Direct mapping]
Cell division cycle protein 16 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 475 aa
54.7 kDa 		No 0
CDC16-006
ENSP00000252457
ENST00000252457
Q13042 [Direct mapping]
Cell division cycle protein 16 homolog
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008283 [cell proliferation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
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 619 aa
71.5 kDa 		No 0
CDC16-007
ENSP00000364459
ENST00000375310
Q13042 [Direct mapping]
Cell division cycle protein 16 homolog
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008283 [cell proliferation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 526 aa
60.4 kDa 		No 0
CDC16-008
ENSP00000364457
ENST00000375308
Q13042 [Direct mapping]
Cell division cycle protein 16 homolog
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008283 [cell proliferation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 526 aa
60.4 kDa 		No 0
CDC16-009
ENSP00000348554
ENST00000356221
Q13042 [Direct mapping]
Cell division cycle protein 16 homolog
A0A024RDZ2 [Target identity:100%; Query identity:100%]
CDC16 cell division cycle 16 homolog (S. cerevisiae), isoform CRA_a
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008283 [cell proliferation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 620 aa
71.7 kDa 		No 0
CDC16-201
ENSP00000353549
ENST00000360383
Q13042 [Direct mapping]
Cell division cycle protein 16 homolog
A0A024RDZ2 [Target identity:100%; Query identity:100%]
CDC16 cell division cycle 16 homolog (S. cerevisiae), isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008283 [cell proliferation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 620 aa
71.7 kDa 		No 0
CDC16-202
ENSP00000486027
ENST00000628084
Q5T8C6 [Direct mapping]
Cell division cycle protein 16 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 475 aa
54.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.