Expression of THEM6 in cancer - Summary - The Human Protein Atlas

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THEM6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	THEM6
Gene description	Thioesterase superfamily member 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA023255
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023255

GENE INFORMATION
Gene name	THEM6 (HGNC Symbol)
Synonyms	C8orf55, DSCD75
Description	Thioesterase superfamily member 6 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	142727203 - 142736927
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130193 (version 83.38)
Entrez gene	51337
UniProt	Q8WUY1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WUY1
Antibodypedia	THEM6 antibodies

PROTEIN BROWSER

THEM6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THEM6-001 ENSP00000338607 ENST00000336138	Q8WUY1 [Direct mapping] Protein THEM6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] Show all	208 aa 23.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.