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GADD45G

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GENERAL INFORMATION

Gene name

 GADD45G

Gene description

 Growth arrest and DNA-damage-inducible, gamma

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Cell line enhanced (HDLM-2, SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA023606
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA023606 A-431 No staining    
HPA023606 SH-SY5Y Nucleus
HPA023606 U-2 OS No staining    

GENE INFORMATION

Gene name

 GADD45G (HGNC Symbol)

Synonyms

 CR6, DDIT2, GADD45gamma, GRP17

Description

 Growth arrest and DNA-damage-inducible, gamma (HGNC Symbol)

Entrez gene summary

 This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q22.2

Chromosome location (bp)

 89605013 - 89606555

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130222 (version 83.38)

Entrez gene

 10912

UniProt

 O95257 (UniProt - Evidence at protein level)

neXtProt

 NX_O95257

Antibodypedia

 GADD45G antibodies

PROTEIN BROWSER
GADD45G-001
GADD45G-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GADD45G-001
ENSP00000252506
ENST00000252506
O95257 [Direct mapping]
Growth arrest and DNA damage-inducible protein GADD45 gamma
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000185 [activation of MAPKKK activity]
GO:0000186 [activation of MAPKK activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007275 [multicellular organismal development]
GO:0030154 [cell differentiation]
GO:0043065 [positive regulation of apoptotic process]
GO:0046330 [positive regulation of JNK cascade]
GO:0051726 [regulation of cell cycle]
GO:1900745 [positive regulation of p38MAPK cascade]
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 159 aa
17.1 kDa 		No 0
GADD45G-002
ENSP00000364924
ENST00000375769
Q5VZ88 [Direct mapping]
Growth arrest and DNA damage-inducible protein GADD45 gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006950 [response to stress]
GO:0051726 [regulation of cell cycle]
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 141 aa
15.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.