Cell atlas - GTPBP3 - The Human Protein Atlas

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GTPBP3

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	GTPBP3
Gene description	GTP binding protein 3 (mitochondrial)
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA042158
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042158	A-431	Mitochondria
	HPA042158	U-2 OS	Mitochondria
	HPA042158	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	GTPBP3 (HGNC Symbol)
Synonyms	FLJ14700, GTPBG3, MSS1, MTGP1, THDF1
Description	GTP binding protein 3 (mitochondrial) (HGNC Symbol)
Entrez gene summary	This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2010]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	17334920 - 17342735
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130299 (version 83.38)
Entrez gene	84705
UniProt	Q969Y2 (UniProt - Evidence at protein level)
neXtProt	NX_Q969Y2
Antibodypedia	GTPBP3 antibodies

PROTEIN BROWSER

GTPBP3-001	GTPBP3-004	GTPBP3-005	GTPBP3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GTPBP3-001 ENSP00000354598 ENST00000361619	Q969Y2 [Direct mapping] tRNA modification GTPase GTPBP3, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006400 [tRNA modification] Show all	514 aa 54.4 kDa	No	0
GTPBP3-004 ENSP00000313818 ENST00000324894	Q969Y2 [Direct mapping] tRNA modification GTPase GTPBP3, mitochondrial Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006400 [tRNA modification] Show all	492 aa 52.1 kDa	No	0
GTPBP3-005 ENSP00000473150 ENST00000600625	Q969Y2 [Direct mapping] tRNA modification GTPase GTPBP3, mitochondrial Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006400 [tRNA modification] Show all	471 aa 49.8 kDa	No	0
GTPBP3-006 ENSP00000351644 ENST00000358792	Q969Y2 [Direct mapping] tRNA modification GTPase GTPBP3, mitochondrial Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006400 [tRNA modification] Show all	524 aa 55.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.