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Most cancer cells displayed moderate to strong cytoplasmic and occasional membranous positivity. Gliomas were weakly stained.
GENE INFORMATION
Gene name
SNX9 (HGNC Symbol)
Synonyms
SDP1, SH3PX1, SH3PXD3A
Description
Sorting nexin 9 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]