Expression of RTN4IP1 in cancer - Summary - The Human Protein Atlas

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RTN4IP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RTN4IP1
Gene description	Reticulon 4 interacting protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA036357
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036357

GENE INFORMATION
Gene name	RTN4IP1 (HGNC Symbol)
Synonyms	NIMP
Description	Reticulon 4 interacting protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a novel mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. The interaction of reticulon 4 with mitochondrial proteins may provide insight into the mechanisms for reticulon-induced inhibition of neurite growth. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	106571971 - 106629487
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130347 (version 83.38)
Entrez gene	84816
UniProt	Q8WWV3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WWV3
Antibodypedia	RTN4IP1 antibodies

PROTEIN BROWSER

RTN4IP1-001	RTN4IP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RTN4IP1-001 ENSP00000358059 ENST00000369063	Q8WWV3 [Direct mapping] Reticulon-4-interacting protein 1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	396 aa 43.6 kDa	No	0
RTN4IP1-201 ENSP00000444261 ENST00000539449	G3V1R2 [Direct mapping] Reticulon-4-interacting protein 1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	226 aa 25 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.