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ARPC1B

GENERAL INFORMATION

Gene name

 ARPC1B

Gene description

 Actin related protein 2/3 complex, subunit 1B, 41kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA004832
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA004832

GENE INFORMATION

Gene name

 ARPC1B (HGNC Symbol)

Synonyms

 ARC41, p40-ARC, p41-ARC

Description

 Actin related protein 2/3 complex, subunit 1B, 41kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 99374249 - 99394801

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130429 (version 83.38)

Entrez gene

 10095

UniProt

 O15143 (UniProt - Evidence at protein level)

neXtProt

 NX_O15143

Antibodypedia

 ARPC1B antibodies

PROTEIN BROWSER
«
ARPC1B-001
ARPC1B-003
ARPC1B-007
ARPC1B-008
ARPC1B-009
ARPC1B-012
ARPC1B-013
ARPC1B-014
ARPC1B-015
ARPC1B-016
ARPC1B-017
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARPC1B-001
ENSP00000252725
ENST00000252725
O15143 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
A4D275 [Target identity:100%; Query identity:100%]
Actin related protein 2/3 complex, subunit 1B, 41kDa; Actin related protein 2/3 complex, subunit 1B, 41kDa, isoform CRA_a; cDNA, FLJ95695, Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa(ARPC1B), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
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 372 aa
40.9 kDa 		No 0
ARPC1B-003
ENSP00000389631
ENST00000451682
O15143 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
A4D275 [Target identity:100%; Query identity:100%]
Actin related protein 2/3 complex, subunit 1B, 41kDa; Actin related protein 2/3 complex, subunit 1B, 41kDa, isoform CRA_a; cDNA, FLJ95695, Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa(ARPC1B), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
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 372 aa
40.9 kDa 		No 0
ARPC1B-007
ENSP00000413173
ENST00000443222
C9K057 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
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 108 aa
12.5 kDa 		No 0
ARPC1B-008
ENSP00000398620
ENST00000414376
C9JBJ7 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
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 102 aa
11.8 kDa 		No 0
ARPC1B-009
ENSP00000408758
ENST00000429246
C9JM51 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 21 aa
2.5 kDa 		No 0
ARPC1B-012
ENSP00000410238
ENST00000455009
C9J4Z7 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
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 128 aa
14.8 kDa 		No 0
ARPC1B-013
ENSP00000413067
ENST00000418347
C9JTT6 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
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 83 aa
9.5 kDa 		No 0
ARPC1B-014
ENSP00000403324
ENST00000417330
C9JEY1 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
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 130 aa
15 kDa 		No 0
ARPC1B-015
ENSP00000398110
ENST00000431816
C9J6C8 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
Show all
 133 aa
15.5 kDa 		No 0
ARPC1B-016
ENSP00000403211
ENST00000427217
C9JFG9 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
Show all
 133 aa
15.5 kDa 		No 0
ARPC1B-017
ENSP00000388802
ENST00000458033
C9JQM8 [Direct mapping]
Actin-related protein 2/3 complex subunit 1B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
Show all
 133 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.