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A few cases of colorectal, breast and pancreatic cancers displayed weak to moderate cytoplasmic and/or membranous positivity. Remaining malignant cells were generally negative.
GENE INFORMATION
Gene name
UNC13A (HGNC Symbol)
Synonyms
KIAA1032, Munc13-1
Description
Unc-13 homolog A (C. elegans) (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012]