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Cancer tissues displayed weak to moderate cytoplasmic and nuclear positivity. Several cases of lymphomas, renal, testicular, liver and endometrial cancers were negative.
GENE INFORMATION
Gene name
SCO2 (HGNC Symbol)
Synonyms
MYP6, SCO1L
Description
SCO2 cytochrome c oxidase assembly protein (HGNC Symbol)
Entrez gene summary
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014]