Tissue expression of PGPEP1 - Summary - The Human Protein Atlas

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PGPEP1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PGPEP1
Gene description	Pyroglutamyl-peptidase I
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA035368
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PGPEP1 (HGNC Symbol)
Synonyms	Pcp, PGP, PGP-I, PGPI
Description	Pyroglutamyl-peptidase I (HGNC Symbol)
Entrez gene summary	Pyroglutamyl peptidase I (EC 3.4.19.3) catalyzes the hydrolysis of N-terminal pyroglutamyl residues from oligopeptides and proteins.[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18340587 - 18369950
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130517 (version 83.38)
Entrez gene	54858
UniProt	Q9NXJ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NXJ5
Antibodypedia	PGPEP1 antibodies

PROTEIN BROWSER

PGPEP1-001	PGPEP1-002	PGPEP1-005	PGPEP1-006	PGPEP1-007	PGPEP1-008	PGPEP1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGPEP1-001 ENSP00000269919 ENST00000269919	Q9NXJ5 [Direct mapping] Pyroglutamyl-peptidase 1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0016920 [pyroglutamyl-peptidase activity] Show all	209 aa 23.1 kDa	No	0
PGPEP1-002 ENSP00000252813 ENST00000252813	Q9NXJ5 [Direct mapping] Pyroglutamyl-peptidase 1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0016920 [pyroglutamyl-peptidase activity] Show all	132 aa 14.6 kDa	No	0
PGPEP1-005 ENSP00000473772 ENST00000604499	S4R2Y9 [Direct mapping] Pyroglutamyl-peptidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0016920 [pyroglutamyl-peptidase activity] Show all	171 aa 18.6 kDa	No	0
PGPEP1-006 ENSP00000473226 ENST00000597663	M0R3H3 [Direct mapping] Pyroglutamyl-peptidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.9 kDa	No	0
PGPEP1-007 ENSP00000475867 ENST00000595066	U3KQG9 [Direct mapping] Pyroglutamyl-peptidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0016920 [pyroglutamyl-peptidase activity] Show all	146 aa 15.9 kDa	No	0
PGPEP1-008 ENSP00000475477 ENST00000597431	U3KQ24 [Direct mapping] Pyroglutamyl-peptidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 12.4 kDa	No	0
PGPEP1-009 ENSP00000471130 ENST00000595552	M0R0B6 [Direct mapping] Pyroglutamyl-peptidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		87 aa 8.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.