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Most cancers displayed weak to moderate granular cytoplasmic immunoreactivity. Hepatocellular carcinomas were strongly stained. A majority of skin, urothelial and renal cancers were negative.
GENE INFORMATION
Gene name
LSM4 (HGNC Symbol)
Synonyms
YER112W
Description
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]