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RNA tissue category: Group enriched (heart muscle, skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skeletal muscle)
GENE INFORMATION
Gene name
HRC (HGNC Symbol)
Synonyms
MGC133236
Description
Histidine rich calcium binding protein (HGNC Symbol)
Entrez gene summary
This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]
P23327 [Direct mapping] Sarcoplasmic reticulum histidine-rich calcium-binding protein
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002027 [regulation of heart rate] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006936 [muscle contraction] GO:0008016 [regulation of heart contraction] GO:0010460 [positive regulation of heart rate] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0030018 [Z disc] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033135 [regulation of peptidyl-serine phosphorylation] GO:0044325 [ion channel binding] GO:0045823 [positive regulation of heart contraction] GO:0051117 [ATPase binding] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055074 [calcium ion homeostasis] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction] GO:1901899 [positive regulation of relaxation of cardiac muscle] GO:1903169 [regulation of calcium ion transmembrane transport]
