Expression of ZNF557 in cancer - Summary - The Human Protein Atlas

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ZNF557

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZNF557
Gene description	Zinc finger protein 557
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA003151 , HPA029291
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable), pancreatic cancer (favourable), lung cancer (favourable) and endometrial cancer (favourable).
Head and neck cancer p<0.001 Pancreatic cancer p<0.001 Lung cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003151	HPA029291

GENE INFORMATION
Gene name	ZNF557 (HGNC Symbol)
Synonyms	MGC4054
Description	Zinc finger protein 557 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	7069444 - 7087968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130544 (version 83.38)
Entrez gene	79230
UniProt	Q8N988 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N988
Antibodypedia	ZNF557 antibodies

PROTEIN BROWSER

ZNF557-001	ZNF557-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF557-001 ENSP00000252840 ENST00000252840	Q8N988 [Direct mapping] Zinc finger protein 557 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	430 aa 49.3 kDa	No	0
ZNF557-002 ENSP00000404065 ENST00000414706	Q8N988 [Direct mapping] Zinc finger protein 557 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	423 aa 48.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.