Cell atlas - OLFM1 - The Human Protein Atlas

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OLFM1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	OLFM1
Gene description	Olfactomedin 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus & cytosol.
RNA cell category	Cell line enhanced (T-47d, SCLC-21H, SiHa, NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Nucleus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA057444
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, SCLC-21H, SiHa, NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus & cytosol.

Main location

Nucleoli (approved)

Additional location

Nucleus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA057444	MCF7	Nucleus
	HPA057444	MCF7	Nucleoli
	HPA057444	U-2 OS	Nucleus
			Nucleoli
			Cytosol

GENE INFORMATION
Gene name	OLFM1 (HGNC Symbol)
Synonyms	AMY, NOE1, NOELIN, OlfA
Description	Olfactomedin 1 (HGNC Symbol)
Entrez gene summary	This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	135075243 - 135121179
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130558 (version 83.38)
Entrez gene	10439
UniProt	Q99784 (UniProt - Evidence at protein level)
neXtProt	NX_Q99784
Antibodypedia	OLFM1 antibodies

PROTEIN BROWSER

OLFM1-001	OLFM1-002	OLFM1-003	OLFM1-004	OLFM1-006	OLFM1-007	OLFM1-009	OLFM1-010	OLFM1-011	OLFM1-012	OLFM1-013	OLFM1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OLFM1-001 ENSP00000252854 ENST00000252854	Q99784 [Direct mapping] Noelin Q6IMJ8 [Target identity:100%; Query identity:100%] NOELIN1_V1; Olfactomedin 1, isoform CRA_c Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003190 [atrioventricular valve formation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005623 [cell] GO:0005783 [endoplasmic reticulum] GO:0007399 [nervous system development] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0023041 [neuronal signal transduction] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030516 [regulation of axon extension] GO:0043025 [neuronal cell body] GO:0043204 [perikaryon] GO:0044295 [axonal growth cone] GO:0060317 [cardiac epithelial to mesenchymal transition] Show all	467 aa 54.1 kDa	Yes	0
OLFM1-002 ENSP00000277415 ENST00000277415	Q99784 [Direct mapping] Noelin Q6IMJ7 [Target identity:100%; Query identity:100%] NOELIN1_V4; Olfactomedin 1, isoform CRA_d Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003190 [atrioventricular valve formation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005623 [cell] GO:0005783 [endoplasmic reticulum] GO:0007399 [nervous system development] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0023041 [neuronal signal transduction] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030516 [regulation of axon extension] GO:0043025 [neuronal cell body] GO:0043204 [perikaryon] GO:0044295 [axonal growth cone] GO:0060317 [cardiac epithelial to mesenchymal transition] Show all	135 aa 15.9 kDa	Yes	0
OLFM1-003 ENSP00000360861 ENST00000371796	Q99784 [Direct mapping] Noelin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003190 [atrioventricular valve formation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005623 [cell] GO:0005783 [endoplasmic reticulum] GO:0007399 [nervous system development] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0023041 [neuronal signal transduction] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030516 [regulation of axon extension] GO:0043025 [neuronal cell body] GO:0043204 [perikaryon] GO:0044295 [axonal growth cone] GO:0060317 [cardiac epithelial to mesenchymal transition] Show all	458 aa 52.8 kDa	No	0
OLFM1-004 ENSP00000360858 ENST00000371793	Q99784 [Direct mapping] Noelin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0003190 [atrioventricular valve formation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005623 [cell] GO:0005783 [endoplasmic reticulum] GO:0007399 [nervous system development] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0023041 [neuronal signal transduction] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030516 [regulation of axon extension] GO:0032281 [AMPA glutamate receptor complex] GO:0043025 [neuronal cell body] GO:0043204 [perikaryon] GO:0044295 [axonal growth cone] GO:0051259 [protein oligomerization] GO:0060317 [cardiac epithelial to mesenchymal transition] GO:0097060 [synaptic membrane] GO:1902003 [regulation of beta-amyloid formation] GO:1902430 [negative regulation of beta-amyloid formation] GO:2001223 [negative regulation of neuron migration] Show all	485 aa 55.3 kDa	Yes	0
OLFM1-006 ENSP00000360864 ENST00000371799	Q6IMJ6 [Direct mapping] NOELIN1_V5; Noelin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		167 aa 18.9 kDa	Yes	0
OLFM1-007 ENSP00000360866 ENST00000371801	Q5VZL8 [Direct mapping] Noelin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 13.8 kDa	Yes	0
OLFM1-009 ENSP00000376717 ENST00000392991	Q99784 [Direct mapping] Noelin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003190 [atrioventricular valve formation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005623 [cell] GO:0005783 [endoplasmic reticulum] GO:0007399 [nervous system development] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0023041 [neuronal signal transduction] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030516 [regulation of axon extension] GO:0043025 [neuronal cell body] GO:0043204 [perikaryon] GO:0044295 [axonal growth cone] GO:0060317 [cardiac epithelial to mesenchymal transition] Show all	153 aa 17.2 kDa	Yes	0
OLFM1-010 ENSP00000340318 ENST00000339720	F8W870 [Direct mapping] Noelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007399 [nervous system development] Show all	163 aa 18.7 kDa	No	0
OLFM1-011 ENSP00000444296 ENST00000539529	F5GZQ2 [Direct mapping] Noelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007399 [nervous system development] Show all	129 aa 15.3 kDa	No	0
OLFM1-012 ENSP00000437906 ENST00000545657	H0YFB9 [Direct mapping] Noelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007399 [nervous system development] Show all	99 aa 11.4 kDa	No	0
OLFM1-013 ENSP00000443806 ENST00000539877	F5H810 [Direct mapping] Noelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007399 [nervous system development] Show all	208 aa 24.2 kDa	No	0
OLFM1-201 ENSP00000479508 ENST00000615948	A0A087WVL1 [Direct mapping] Noelin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		168 aa 18.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.