Expression of LSP1 in cancer - Summary - The Human Protein Atlas

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LSP1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LSP1
Gene description	Lymphocyte-specific protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi, HDLM-2, RPMI-8226)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA019693 , CAB017781
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), cervical cancer (favourable) and glioma (unfavourable).
Endometrial cancer p<0.001 Cervical cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019693	CAB017781

GENE INFORMATION
Gene name	LSP1 (HGNC Symbol)
Synonyms	WP34
Description	Lymphocyte-specific protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	1852970 - 1892267
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130592 (version 83.38)
Entrez gene	4046
UniProt	P33241 (UniProt - Evidence at protein level)
neXtProt	NX_P33241
Antibodypedia	LSP1 antibodies

PROTEIN BROWSER

LSP1-001	LSP1-002	LSP1-004	LSP1-005	LSP1-006	LSP1-007	LSP1-008	LSP1-010	LSP1-013	LSP1-014	LSP1-015	LSP1-016	LSP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LSP1-001 ENSP00000371194 ENST00000381775	P33241 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004871 [signal transducer activity] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0006952 [defense response] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	467 aa 50.4 kDa	No	0
LSP1-002 ENSP00000384022 ENST00000406638	P33241 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004871 [signal transducer activity] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	277 aa 30.2 kDa	No	0
LSP1-004 ENSP00000308383 ENST00000311604	P33241 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004871 [signal transducer activity] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	339 aa 37.2 kDa	No	0
LSP1-005 ENSP00000383932 ENST00000405957	P33241 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004871 [signal transducer activity] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	277 aa 30.2 kDa	No	0
LSP1-006 ENSP00000414106 ENST00000451814	C9JNQ1 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		64 aa 7.1 kDa	No	0
LSP1-007 ENSP00000400346 ENST00000457279	E7EMG9 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0007165 [signal transduction] Show all	275 aa 30.6 kDa	No	0
LSP1-008 ENSP00000416363 ENST00000417766	E9PBD8 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0007165 [signal transduction] Show all	222 aa 24.4 kDa	No	0
LSP1-010 ENSP00000412405 ENST00000432093	E9PBD8 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0007165 [signal transduction] Show all	222 aa 24.4 kDa	No	0
LSP1-013 ENSP00000411191 ENST00000421485	C9J9B9 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		60 aa 6.6 kDa	No	0
LSP1-014 ENSP00000402543 ENST00000446808	C9JKF7 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0007165 [signal transduction] Show all	126 aa 13.9 kDa	No	0
LSP1-015 ENSP00000400999 ENST00000429923	C9JU59 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0007165 [signal transduction] Show all	175 aa 19.5 kDa	No	0
LSP1-016 ENSP00000403460 ENST00000418975	C9JDV1 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0007165 [signal transduction] Show all	122 aa 13.5 kDa	No	0
LSP1-201 ENSP00000484140 ENST00000612798	P33241 [Direct mapping] Lymphocyte-specific protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004871 [signal transducer activity] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	277 aa 30.2 kDa	No	0

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The Human Protein Atlas

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