Expression of COL5A1 in cancer - Summary

GENERAL INFORMATION
Gene name	COL5A1
Gene description	Collagen, type V, alpha 1
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ, SiHa)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in connective tissue and extracellular matrix positivity in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA030769
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA030769

GENE INFORMATION
Gene name	COL5A1
Synonyms
Description	Collagen, type V, alpha 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	134641774 - 134844843
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130635 (version 83.38)
Entrez gene	1289
UniProt	P20908 (UniProt - Evidence at protein level)
neXtProt	NX_P20908
Antibodypedia	COL5A1 antibodies

PROTEIN BROWSER

COL5A1-001	COL5A1-003	COL5A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL5A1-001 ENSP00000360882 ENST00000371817	P20908 [Direct mapping] Collagen alpha-1(V) chain A0A024R8E5 [Target identity:100%; Query identity:100%] Collagen, type V, alpha 1, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001568 [blood vessel development] GO:0003007 [heart morphogenesis] GO:0005178 [integrin binding] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005588 [collagen type V trimer] GO:0005604 [basement membrane] GO:0005788 [endoplasmic reticulum lumen] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0016477 [cell migration] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0032964 [collagen biosynthetic process] GO:0035313 [wound healing, spreading of epidermal cells] GO:0035989 [tendon development] GO:0043206 [extracellular fibril organization] GO:0043394 [proteoglycan binding] GO:0043588 [skin development] GO:0045112 [integrin biosynthetic process] GO:0046872 [metal ion binding] GO:0048407 [platelet-derived growth factor binding] GO:0048592 [eye morphogenesis] GO:0051128 [regulation of cellular component organization] GO:0070062 [extracellular exosome] GO:1903225 [negative regulation of endodermal cell differentiation] Show all	1838 aa 183.6 kDa	Yes	0
COL5A1-003 ENSP00000360885 ENST00000371820	H7BY82 [Direct mapping] Collagen alpha-1(V) chain Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005581 [collagen trimer] Show all	210 aa 23.5 kDa	No	0
COL5A1-201 ENSP00000481360 ENST00000618395	A0A087WXW9 [Direct mapping] Collagen alpha-1(V) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] Show all	1838 aa 183.7 kDa	Yes	0